Fipronil is a phenylpyrazole insecticide that widely used as pesticide and veterinary drug, although studies suggest it could be toxic to mammals. The objectives of this study were examine the pharmacokinetic profile fipronil in mice, dogs, cats, evaluate its effects on emotional cognitive behaviors dogs cats using data obtained from mice. assessment vivo kinetics was conducted mice dogs. We al...

Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown also other substrates, such as amino acids, for energy expenditure various conditions. Here, we report the new physiological of proton-coupled acid transporters, SLC36A2 SLC36A3, on global metabolism. The relative mRNA expression levels both Slc36a2 Slc36a3 were a...

background: trace elements play an important role in a number of biological processes. astaxanthin (asx), a carotoid pigment found in certain marine plant and animals, has shown anti cancer and anti free radical properties. this work intended to understand the effect of astaxanthin in breast cancer (invasive ductal carcinoma, idc) by using micro-pixe method. for this aim the concentration of tr...

background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...

This investigation was undertaken to assess the combined effects of protein restriction and ultrasonic energy exposure during pregnancy on the maternal and fetal mouse. Pregnant female mice were fed diets containing either 18% casein (control diet) or 6% casein (restricted protein diet) during gestation. All animals were subjected to the ultrasonic exposure procedure (actual: 2.5 W/cm2 spatial ...

Background: One in every 250 newborns is exposed to antiepileptic drugs, inutero .The risk of congenital malformations in newborns, prenatally exposed to antiepileptic drugs (AEDs), is around 5% which is 2 to 2.5 times that of general population; while carbamazepine (CBZ) and valproate (VPA) still provide the treatment of choice in most forms of epilepsy, being efficacious in approximately two-...

Abstract Obesity is associated with increased deposition of fat in ectopic tissues, such as within the liver and visceral adipose depots, including omentum mesentery. Increased an accompanying feature metabolic syndrome end-organ damage NAFLD. Emerging evidence implicates intrahepatic B cells progression NAFLD, number proinflammatory have been found steatotic livers HFD-fed mice. Our preliminar...

Control of the expression of the human insulin-like growth factor II gene is known to be complex, displaying both tissue-specific and developmental regulation. Insulin-like growth factor II is expressed at high levels in most tissues in the human fetus and appears to be important in fetal growth. In adult life, high levels of expression are found chiefly in liver, kidney, skin, nerve, and muscl...

perfluorooctanesulfonate (pfos) is a widely spread environmental contaminant. it accumulates in the brain and has potential neurotoxin effects. due to chemical properties, pfos shows persistency in the environment and therefore has potential hazardous effect. the risk of possible intra uterine exposure to pfos poses a health concern for developmental effects. the goal of this study was survey o...