C57BL/6J (B6) mice containing the Mus domesticus poschiavinus Y chromosome, YPOS, develop ovarian tissue, whereas testicular tissue develops in DBA/2J or 129S1/SvImJ (129) mice containing the YPOS chromosome. To identify genes involved in sex determination, we used a congenic strain approach to determine which chromosomal regions from 129Sl/SvImJ provide protection against sex reversal in XYPOS...

objective: safety of lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. this study aimed to identify the effect of l. citriodora aqueous extract on pregnancy outcome in mice. materials and methods: timed-pregnant mice received doses of 0.5 g/kg/day l. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. maternal body weights wer...

The fetal toxicities of multi-wall carbon nanotubes (MWCNTs) with various sizes were compared in CD1(ICR) mice. MWCNTs were suspended in 2% sodium carboxymethyl cellulose solution in phosphate-buffered saline. On day 9 of gestation, dams were administered a single intraperitoneal dose of MWCNTs (4 mg/kg body weight), while dams in the control group were administered vehicle (10 mL/kg body weigh...

Toxoplasmosis is an important zoonotic disease that can cause abortion in humans and animals. The aim of this study was isolation and subsequent genotyping of Toxoplasma gondii isolates in ovine aborted fetuses. During 2012-2013, 39 ovine aborted fetuses were collected from sheep flocks in Khorasan Razavi Province, Iran. The brain samples were screened for detection of the parasite DNA by neste...

A significant correlation was shown in Rockland-Swiss albino mice between the number of fetuses and maternal nest-building performance as assessed by the amount of nesting material gathered into the cage. The greater the number of fetuses, the more nesting material was gathered. A significant correlation first appeared on Day 4 and was maintained until Day 18 of gestation.

Background: Sperm DNA damage (SDD) is a significant male infertility factor, yet it is not routinely diagnosed or treated in couples undertaking fertility treatment by ART. Men with this condition are likely to experience sub-fertility or infertility, expose their female partners to greater risk of miscarriage and pass on de novo sporadic DNA mutations potentially compromising the health of the...

conclusions our data showed that inhalation of diazinon during pregnancy increased the hepatocyte area and hepatocyte apoptosis while it decreased the sinusoid area of the fetal liver. materials and methods twenty-five pregnant balb/c mice (25 - 30 gr) were divided into five equal groups in the animal lab of baqiyatallah university of medical sciences, tehran, iran. the normal group was without...

Cigarette smoke (CS) and ethanol (EtOH) are known to synergize in the causation of cancers of the upper aerodigestive tract and of the liver. Little is known about possible interactions between these agents in other organs. These premises prompted us to evaluate the clastogenic effects resulting from the inhalation for 3 weeks of mainstream CS and oral administration of EtOH, which were tested ...

OBJECTIVE To evaluate the effects of Prunus domestica L. extracts on fetuses and neonatal skeletal systems. MATERIALS AND METHODS A total of 32 pregnant mice (Mus musculus) received vehicle and plum hydroalcoholic extract at gestational days 1-18 and during the entire gestational period as well as 10 days postpartum, respectively. A total of 30 nonpregnant mice were fed plum hydroalcoholic ex...