microbiological analyses of soil chronically exposed to petroleum complex compounds of some oil springs in south of iran resulted in isolation and purification of a new native thermophilic strain which is capable to desulfurize petroleum sulfur compounds by 4-s mechanism. dibenzothiophene (dbt) was selected as a complex sulfur compound model and many experiments were done to identify the metabo...

dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (vm) and the michaelis-menten constant (km) in a concerned population. the aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of iranian patients to optimize the antiepileptic pharmacotherapy. fourty patients who received a constant dose of phenytoin ...

A Michaelis-Menten (MM)-like kinetic model for pulmonary clearance and retention of insoluble dusts was developed and validated by comparing our predictions with experimental data from F344 rats. Published data from inhalation studies involving accumulation and elimination of photocopy test toner, antimony trioxide, carbon black, and diesel exhaust particles were investigated. Numerical integra...

Risk-based assessment methods are commonly used at the contaminated sites by hydrocarbon pollutants. This paper presents the results of a two-dimensional finite volume model of reactive transport of biodegradable BTEX which have been developed for the saturated zone of an unconfined aquifer in the Pump station area of Tehran oil refinery, Iran. The model governing equations were numerically sol...

The electrocatalytic oxidation of vitamin B6 (pyridoxine hydrochloride) was demonstrated on a Nafion/lead ruthenate pyrochlore modified electrode (designated as NCME) by cyclic voltammetry. The catalytic activity of vitamin B6 was explored in terms of the higher oxidation state of ruthenium species, i.e., Py-Ru/Ru in the pyrochlore network (Py). The mediated mechanism was derived by Michaelis-M...

The basis of enzyme kinetic modelling was established during the early 1900’s when the work of Leonor Michaelis and Maud Menten produced a pseudo-steady state equation linking enzymatic catalytic rate to substrate concentration (Michaelis & Menten, 1913). Building from the Michaelis-Menten equation, other equations used to describe the effects of modifiers of enzymatic activity were developed b...

The authors generalise the concept of the geometric phase in stochastic kinetics to a non-cyclic evolution. Its application is demonstrated on kinetics of the Michaelis-Menten reaction. It is shown that the non-periodic geometric phase is responsible for the correction to the Michaelis-Menten law when parameters, such as a substrate concentration, are changing with time. The authors apply these...

catalytic isomerization of glucose to fructose by immobilized glucose isomerase in an aqueous-ethanol medium was studied. using michaelis-menten equation and haldane relationship, the main kinetic parameters were determined: kmf, vmf, kmr, vmr. by comparing the aqueous-ethanol medium with an aqueous solution, the measured values of kmr and kmf were increased in the aqueous-ethanol solution, whi...

Studies were performed to investigate the UDP-glucuronosyltransferase enzyme(s) responsible for the human liver microsomal N2-glucuronidation of the anticonvulsant drug lamotrigine (LTG) and the mechanistic basis for the LTG-valproic acid (VPA) interaction in vivo. LTG N2-glucuronidation by microsomes from five livers exhibited atypical kinetics, best described by a model comprising the express...