AbstractSingleand multicriteria evolution strategies are implemented to optimize micro-fluidic devices, namely the shape of a microchannel used for bioanalysis and the mixing rate in a micromixer used for medical applications. First, multimembered evolution strategies employing mutative step size adaptation are combined with the Strength Pareto Approach. In order to support targetting, an exten...

We present a continuous-flow active micromixer based on channel-wall deflection in a polydimethylsiloxane (PDMS) chip for volume flows in the range up to 2 μL s −1 which is intended as a novel unit operation for the microfluidic Braille pin actuated platform. The chip design comprises a main microchannel connected to a series of side channels with dead ends aligned on the Braille pins. Computer...

micromixers are one of the most crucial components of lab-on-a-chip devices with the intention of mixing and dispersion of reagents like small molecules and particles. the challenge facing micromixers is typically insufficient mixing efficiency in basic designs, which results in longer microchannels. therefore, it is desirable to increase mixing efficiency, in order to decrease mixing length, w...

Biodegradable polymeric nanoparticles are considered as promising drug delivery systems due to their high potential in tuning the release and alleviate side effects. However, particle greater than 200 nm can be detected by immune system. Thus, this paper focuses on elaboration of size-controlled poly (lactic-co-glycolic acid) smaller encapsulating a model drug. For purpose, biodegradable polyme...

The Koch-Haaf reaction of adamantanols was successfully carried out in a microflow system at room temperature. By combining an acid-tolerant hastelloy-made micromixer, a PTFE tube, and a hastelloy-made microextraction unit, a packaged reaction-to-workup system was developed. By means of the present system, the multigram scale synthesis of 1-adamantanecarboxylic acid was achieved in ca. one hour...

This study aims to perform optimizatione achieve the best diffusion control between channels by designing and analysing a microfluidic-based micromixer. The design analysis of micromixer were made with COMSOL Multiphysics program. Some input output parameters must be defined for Among these parameters, inputs are coefficient inlet flow rate, while outputs velocity, pressure, concentration. Each...

This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator p...