AIM To assess allelic imbalance and microsatellite instability in the region of the "deleted in colorectal cancer" (DCC) gene on chromosome 18q using fluorescent DNA technology in colorectal cancer in patients under the age of 35. METHODS Thirty two cases of colorectal cancer in patients under the age of 35 and with no family history of colon cancer were retrieved. DNA was extracted by standa...

abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

The azimuthal version of the magnetorotational instability (MRI) is a nonaxisymmetric instability of a hydrodynamically stable differentially rotating flow under the influence of a purely or predominantly azimuthal magnetic field. It may be of considerable importance for destabilizing accretion disks, and plays a central role in the concept of the MRI dynamo. We report the results of a liquid m...

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 an...

Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...

Somatic DNA alterations are known to occur in atherosclerotic carotid artery lesions; however, their significance is unknown. The accumulation of microsatellite mutations in coding DNA regions may reflect a deficiency of the DNA mismatch repair (MMR) system. Alternatively, accumulation of these coding microsatellite mutations may indicate that they contribute to the pathology. To discriminate b...