Contrast-induced acute kidney injury (CI-AKI) is an intrinsic caused by contrast injection in susceptible individuals. Although the pathophysiological mechanisms which agents induce have not been completely explained, direct and indirect effects, as well hemodynamic perturbations, suggested. Renal effects develop immediately after injection, and, theoretically, they could be detected early usin...

UNLABELLED Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particularly diarrhea, are frequently observed as a side effect following MPA therapy. We recently reported that MPA altered the tight junction (TJ)-mediated barrier function in a Caco-2 cell monolayer model system. This study investigates whether...

Abstract Background The current coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has emerged in Wuhan, China, and rapidly become a global challenge, creating major challenges to health systems almost every country the world it turned into pandemic. COVID-19 poses risky clinical situation that can range from mild illness failure, requiring a...

The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and autoimmune encephalitis have been shown to ...