This clinical policy provides evidence-based recommendations on select issues in the management of adult patients with mild traumatic brain injury (TBI) in the acute setting. It is the result of joint efforts between the American College of Emergency Physicians and the Centers for Disease Control and Prevention and was developed by a multidisciplinary panel. The critical questions addressed in ...

Mild traumatic brain injury (TBI) is characterized by acute physiological changes that result in at least some acute cognitive difficulties and typically resolve by 3 months postinjury. Because the majority of mild TBI patients have normal structural magnetic resonance imaging (MRI)/computed tomography (CT) scans, there is increasing attention directed at finding objective physiological correla...

Insulin-like growth factors (IGF) are potent neurotrophic and neurorepair that were recently proposed as biomarkers of traumatic brain injury (TBI) associated psychiatric comorbidities, in particular post-traumatic stress disorder (PSTD). We tested the hypothesis IGF system is differentially deregulated acute early chronic stages TBI, under stress. Plasma IGF1 IGF2 levels evaluated mice 3 weeks...

introduction: this study was designed to investigate the effects of granulocyte colony-stimulating factor (g-csf) administration in rats for 6 weeks after traumatic brain injury (tbi). methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into four groups. the treatment groups (n = 10 each) were injected subcutaneously with recombinant human g-...

traumatic brain injury (tbi) is a global health concern that typically causes emotional disturbances and cognitive dysfunction. it elicits a complex secondary injury response, with neuroinflammation as a crucial central component. secondary pathologies following tbi may be associated with chronic neurodegenerative disorders and an enhanced likelihood of developing dementia-like disease in later...

OBJECTIVE To investigate the extent to which neuropsychologic and functional outcome after complicated mild traumatic brain injury (TBI) parallels that of moderate TBI recovery. DESIGN A longitudinal study comparing neuropsychologic and functional status of persons with complicated mild TBI and moderate TBI at discharge from inpatient rehabilitation and at 1 year postinjury. SETTING Rehabil...

MAIN RESULTS After one year, prevalence of psychiatric illness significantly increased in people with moderate to severe and mild traumatic brain injury, compared with controls (moderate to severe: 49%; mild: 34%; control: 18%; see table 1, http://www.ebmentalhealth.com/ supplemental). People with prior psychiatric illness are more likely to suffer from a psychiatric illness after traumatic bra...

working memory impairment is one of the most important cognitive deficits in patients with mild traumatic brain injury that affect mental health status even in the early stages of the disease. the purpose of this study was to evaluate the correlation between the working memory and mental health status in traumatic brain injury (tbi) patients. this cohort study was performed on 50 tbi patients a...

Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on structure of tau and normal physiological functions, including in hibernation changes throughout estrus cycle. There are many pathways involved phosphorylating diabetes, stroke, Alzheimer’s disease (AD), brain injury, aging, drug use. ...

Traumatic brain injury (TBI) is an important public health issue as these high-rate mechanical insults to tissue, even on a mild scale, progress secondary cascades that prolong and augment the injury. More effective models are vital study mechanism progression. Although oligodendrocyte progenitor cells (OPCs) mature oligodendrocytes (OLs) have been shown play large role in TBI recovery, researc...