BACKGROUND Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. PATIENTS AND METHODS Forty-one thousand five hundred and twenty-three CUP patient...

Cancer of unknown primary site (CUP) is a fatal cancer diagnosed through metastases at various organs. Little is known about germline genetics of CUP which appears worth of a search in view of reported familial associations in CUP. In the present study, samples from CUP patients were identified from 2 Swedish biobanks and a German clinical trial, totaling 578 CUP patients and 7628 regionally ma...

Navigation of the cup in total hip arthroplasty is well analyzed and shows accurate results, reducing cup outliers of Lewinnek's "safe zone." With regard to the combined anteversion of cup and stem, however, a "new" safe zone with a range of 25° to 50° has been published. The aim of this study was to analyze total anteversion (cup and stem) by postoperative 3D computed tomography in isolated cu...

In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for posterior patterning. This precision is accomplished by a localization-dependent translational control mechanism that ensures translation of only correctly localized oskar transcripts. Although progress has been made in identifying localization factors and translational repressors of oskar, none of ...

Captain and Quartermaster, R.A.M.C.(T.) ; Steward, Southmead Hospital. Thomas Jones began his career with the Guardians of the Parish of Lambeth in 1896, and was subsequently Master of Alresford Workhouse, Hants., from 1903 to 1905. Then, coming to Bristol, he was successively Storekeeper and Master's Clerk at Eastville Institution until he was promoted to be Steward at Southmead Infirmary in S...

at Head-Quarters. Gentlemen, I have already notified to you the appointments to which you have been nominated by the Hon'ble the GovernorGeneral and Council in pursuance of a new arrangement made by the Hon'ble Court of Directors for the reform of their Medical Departments and for the conduct of their military hospitals. This arrangement has been prescribed in a separate General letter from the...

Shortly after war broke out in 1914 Dr Flora Murray and Dr Louisa Garrett Anderson, two former members of the Women’s Social and Political Union, founded their own women’s hospital organization to care for soldiers wounded in the fighting. Experience in the suffrage movement had taught them what the likely reaction of the authorities would be to any offer of help from women doctors, so they app...