background and objectives: milk thistle (silybum marianum), a medicinal plant of the asteraceae family that have been used long time ago, in the treatment of liver disease. sowing date of this plant has not been determined, therefore, this study was necessary. this plant was identified as a weed, this plant is identified as a weed, while silymarin in the seeds are used in the anti-hepatitis and...

Silymarin, an extract of the seeds of Silybum marianum L. (milk thistle), is used for treatment of liver diseases. It contains several active flavonolignans; the major are silybin, which is a mixture of diastereomers A and B, and silychristin. Low bioavailability of silybin and silychristin is related to low water solubility of these compounds. In order to enhance the solubility, S. marianum dr...

background: this study was conducted to determine the efficacy of milk thistle seeds (mtss) in counteracting the toxic effects of aflatoxin b1 (afb1) in a contaminated diet fed to broilers.methods: two dietary inclusion rates of afb1 (0, 0.250 and 500 ppb) and mts (0, 0.5 and 1%) were tested in a 3×3 factorial manner. the effect of nine experimental treatments was assessed using 216 one-d-old r...

The standardized extract contains flavonolignans, collectively referred to as silymarin. Sometimes the extract itself is called “silymarin”, which can lead to confusion over dosage since the level of flavonolignans (silymarin) in the extract is typically 60 to 80%, depending on the test methodology used. The main flavonolignans found in the extract are silybin (silibin), silychristin, silydiani...

The flavolignans silybin (1) and 2,3-dehydrosilybin (2) (Figure 1) were isolated from fruits of milk thistle [Silybum marianum (L). Gaertn.] cultivated in the Samara region (Russian Federation). 2,3-dehydrosilybin (2) for the first time in Russian Federation is described for the given plant. Silybin and 2,3-dehydrosilybin and also new preparation, a fluid extract of Silybum marianum fruits, hav...

Globally, the risk of colorectal cancer (CRC) as well as the incidence of mortality associated with CRC is increasing. Thus, it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents, for the prevention of CRC. The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progre...