The tonalness spectrum shows the likelihood of a spectral bin being part of a tonal or non-tonal component. It is a non-binary measure based on a set of established spectral features. An easily extensible framework for the computation, selection, and combination of features is introduced. The results are evaluated and compared in two ways. First with a data set of synthetically generated signal...

Response 4: The introduction will be changed to contain: Sussmann et al. 2013 did a similar study on the inter-comparison of methane from MIR and NIR retrievals. They used a Tikhonov-L1 regularized profile retrieval scheme with the standard NDACC retrieval package SFIT2 for the MIR and the standard TCCON retrieval (GFIT) for the NIR spectra. They conclude that the obtainable information from th...

Breast cancer is a leading cause of related death among women worldwide and it complex disease characterized by its heterogeneity. The heterogenous characteristic the breast responsible for aggressiveness treatment resistance. stem cells (BCSCs) are population with increased propensity proliferation, differentiation, migration, invasion mammosphere formation resistance to treatment. They have a...

objective: the aim of the present study was the production of recombinant lentviruses that express mir-16. after transduction, altered expression levels of mirna and its target protein were analyzed. methods: a dna fragment that contained the mir-16 precursor was cloned in a lentiviral plasmid. lentiviral vector particles were produced by transient calcium phosphate co-transfection of 293t cell...

Objective(s): Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by the accumulation of myeloid cells with a chromosomal translocation known as the Philadelphia chromosome. In this study, we investigated the roles of miR-570 in CML development. Materials and Methods: Expression of miR-570 in CML samples and cell lines was determined by qRT-PCR. Glucose upt...

Purpose: Glioblastoma is an aggressive and incurable brain tumor whose progression driven in part by glioblastoma stem cells, which are also responsible for the tumor’s low therapy efficacy. The maintenance expansion of cell population promoted hypoxic microenvironment, where miRNAs play fundamental roles their survival. Methods: GBM stem-like cells were isolated from three parental lines. then...