BACKGROUND SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate. Previously, we demonstrated that SOX2 plays important roles in growth inhibition through cell cycle arrest and apoptosis, and that SOX2 expression is frequently down-regulated in gastric cancers. However, the mechani...

BACKGROUND Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. We have investigated the prognostic impact of Dicer and Drosha and their correlation with miR-126 expression in a large cohort of non-small cell lung cancer (NSCLC) patients. We ...

Aging research is currently focusing on circulating functional markers that can help discriminate the mechanisms of physiological aging from those of agerelated diseases (ARDs). The cellular model of choice for this type of studies, cell senescence, has been providing highly valuable information. Senescent cells are characterized by permanent cell cycle arrest and acquisition of a senescence-as...

s 5285–5294 5285 Differentiation of Cardiac Progenitor Cells Into Myocytes Is Regulated by miR-499 Toru Hosoda, Hanqiao Zheng, Noriko Ide-Iwata, Domenico D’Amario, Konrad Urbanek, Marcello Rota, Jan Kajstura, Piero Anversa, Annarosa Leri; Brigham & Womens Hosp, Boston, MA Cardiac progenitor cells (CPCs) delivered to the infarcted heart generate a large number of small cardiomyocytes which fail ...

s 5285–5294 5285 Differentiation of Cardiac Progenitor Cells Into Myocytes Is Regulated by miR-499 Toru Hosoda, Hanqiao Zheng, Noriko Ide-Iwata, Domenico D’Amario, Konrad Urbanek, Marcello Rota, Jan Kajstura, Piero Anversa, Annarosa Leri; Brigham & Womens Hosp, Boston, MA Cardiac progenitor cells (CPCs) delivered to the infarcted heart generate a large number of small cardiomyocytes which fail ...

RATIONALE A high-fat diet accompanied by hypertriglyceridemia increases an individual's risk for development of atherosclerosis. An early event in this process is monocyte recruitment through binding to vascular cell adhesion molecule 1 (VCAM-1) upregulated on inflamed arterial endothelium. Diets high in polyunsaturated fatty acids (PUFAs) may provide athero-protection by ameliorating this effe...

Atherosclerotic coronary artery disease (CAD) continues to be an important socioeconomic problem and the leading cause of death in the Western world. Several cellular components, including endothelial, inflammatory, and smooth muscle cells of the arterial wall, participate in the generation of an atherosclerotic plaque,1 the growth of which is responsible for a progressive narrowing of the lume...

PERIPHERAL ARTERIAL DISEASE (PAD) is a global health issue, affecting 202 million people worldwide (12, 18). The most common symptom of PAD is intermittent claudication. Although claudication patients have a limited progression to chronic limb ischemia, PAD is associated with increased risk of cardiovascular morbidity and mortality (8). This fact, along with the impact on lifestyle and the larg...