نتایج جستجو برای: mirna mrna regulatory network
تعداد نتایج: 991763 فیلتر نتایج به سال:
The epithelial cell adhesion molecule (EpCAM) is highly expressed in the liver during development and diseases. However, its role pathology of remains to be explored. tissues EpCAM-/- wildtype (WT) mice at P0 stage were used for RNA sequencing. differently miRNAs, lncRNAs mRNAs selected confirmed by qPCR. expression metabolism-related gene SET domain bifurcated 2 (Setdb2) was significantly incr...
Osteosarcoma remains a leading cause of cancer death in children and young adolescents. Although the introduction of multiagent chemotherapy, survival rates have not improved in two decades. Therefore, it is urgently needed to know the details regarding molecular etiology to driving therapeutic inroads for this disease. In this study we performed an integrated analysis of miRNA and mRNA express...
Blood consists of different cell populations with distinct functions and correspondingly, distinct gene expression profiles. In this study, global miRNA expression profiling was performed across a panel of nine human immune cell subsets (neutrophils, eosinophils, monocytes, B cells, NK cells, CD4 T cells, CD8 T cells, mDCs and pDCs) to identify cell-type specific miRNAs. mRNA expression profili...
OBJECTIVE The goal of our study was to identify the regulatory mechanisms of gene expression mediated by miRNAs and DNA methylation in colon adenocarcinoma (COAD). MATERIALS AND METHODS The miRNAs and mRNAs expression and DNA methylation data of COAD and adjacent normal tissues were obtained from The Cancer Genome Atlas (TCGA) database. Based on the differentially expressed miRNAs and mRNAs...
Objective The study aimed to explore the miRNA and mRNA biomarkers in post-stroke depression (PSD) develop a miRNA–mRNA regulatory network reveal its potential pathogenesis. Methods transcriptomic expression profile was obtained from GEO database using accession numbers GSE117064 (miRNAs, stroke vs. control) GSE76826 [mRNAs, late-onset major depressive disorder (MDD) control]. Differentially ex...
Objective: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked cardiovascular disease. Approach Results: Microarray analysis revealed 547 differentially expressed genes, mainly involved inflammatory, cardiovascular, reproductive disorders. Besides, this appr...
Identification of miRNA-mRNA modules is an important step to elucidate their combinatorial effect on the pathogenesis and mechanisms underlying complex diseases. Current identification methods primarily are based upon miRNA-target information and matched miRNA and mRNA expression profiles. However, for heterogeneous diseases, the miRNA-mRNA regulatory mechanisms may differ between subtypes, lea...
Previous studies have revealed that the deregulation of circulating miRNAs is associated with liver cirrhosis. The present study aimed to identify reliable candidate biomarkers to improve the early detection of liver cirrhosis. An integrated analysis of expression profiles of microRNAs (miRNAs/miRs) and mRNAs in liver cirrhosis tissues from the GEO database was performed. Next, the regulatory t...
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