Mice homozygous for a defect in the PTCD2 (pentatricopeptide repeat domain protein 2) gene were generated in order to study the role of this protein in mitochondrial RNA metabolism. These mice displayed specific but variable reduction of ubiquinol-cytochrome c reductase complex activity in mitochondria of heart, liver and skeletal muscle due to a decrease in the expression of mitochondrial DNA-...

Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...

Geological events and landscape features, as well changes in the climate during Pliocene period, have shaped distribution of genetic diversity demographic history freshwater fish mainland China. In this study, we investigated phylogeny population structure Acrossocheilus species (A. fasciatus, A. kreyenbergii wenchowensis) Zhejiang region by mitochondrial cytochrome b (cyt-b) control (D-loop) s...

Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...

chloroacetaldehyde (caa) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). in this research, the cytotoxic mechanisms of caa in freshly isolated rat hepatocytes were investigated.caa cytotoxicity was associated with reactive oxygen spec...

Direct sequencing of mitochondrial DNA (mtDNA) following amplification using the polymerase chain reaction (PCR) has found widespread use in population genetic and phylogenetic research over the past few years. Recently, nuclear copies of mitochondrial genes have been reported in diverse eukaryotic species, often confounding such research (reviewed in [2,3]). Under certain circumstances, nuclea...

The genus Bionychiurus Pomorski, 1996 is not recorded from India so far. A new species nominated as tamilensis sp. n. described the Nilgiri Hills in Western Ghats. possess a dorsal pso formula 32/133/33,343 and ventral 11/011/11,121. similar to changbaiensis, B. normalis, oblongatus reported China Korea. 658 bp mitochondrial cytochrome oxidase subunit I DNA region (COX1) of was sequenced for it...

Background: There are two fundamental forms of cell death: apoptosis and necrosis. Molecular studies of cell death thus far favor a model in which apoptosis and necrosis share very few molecular regulators. It appears that apoptotic processes triggered by a variety of stimuli converge on the activation of a member of the caspase family, such as caspase 3, which leads to the execution of apoptos...

We found distinct pelage characters in Finlayson’s squirrel (Callosciurus finlaysonii) population, which is endemic to Lao Island of the Cham Islands, located off coast central Vietnam. Among squirrels ‘C. erythraeus-finlaysonii complex’, consists all forms C. erythraeus and finlaysonii, mitochondrial cytochrome-b sequences show that a cluster with finlaysonii external flavimanus, defined previ...