نتایج جستجو برای: mitochondrial genetics
تعداد نتایج: 205653 فیلتر نتایج به سال:
Several recent studies have confirmed that mitochondrial DNA variation and evolution are not consistent with the neutral theory of molecular evolution and might be inappropriate for estimating effective population sizes. Evidence for the action of both positive and negative selection on mitochondrial genes has been put forward, and the complex genetics of mitochondrial DNA adds to the challenge...
Understanding mitochondrial role in normal physiology and pathological conditions has proven to be of high importance as mitochondrial dysfunction is connected with a number of disorders as well as some of the most common diseases (e.g. diabetes or Parkinson's disease). Modeling mitochondrial dysfunction has been difficult mainly due to unique features of mitochondrial genetics. Here we discuss...
Chlamydomonas reinhardtii is now becoming a useful model for the study of mitochondrial genetics in a photosynthetic organism. The small (15.8 kb) mitochondrial genome C. reinhardtii has been sequenced completely and all the genes have been identified. Several mutants inactivated in mitochondrial genes encoding components of the respiratory complexes I, III and IV have been characterized at the...
how to cite this article: khatami m, heidari mm, mansouri r, mousavi f. the polg polyglutamine tract variants in iranian patients with multiple sclerosis. iran j child neurol. 2015 winter; 9(1):37-41. abstract objective multiple sclerosis (ms) is a common disease of the central nervous system. the interaction between inflammatory and neurodegenerative processes typically results in irregular ne...
The genetics of mitochondrial disease: dissecting mitochondrial pathology using multi‐omic pipelines
Over the past 10 years, mitochondrial defects have been implicated in a wide variety of degenerative diseases, aging, and cancer. Studies on patients with these diseases have revealed much about the complexities of mitochondrial genetics, which involves an interplay between mutations in the mitochondrial and nuclear genomes. However, the pathophysiology of mitochondrial diseases has remained pe...
DISEASE MUTATIONS IN THE HUMAN MITOCHONDRIAL DNA POLYMERASE THUMB SUBDOMAIN IMPART SEVERE DEFECTS IN MtDNA REPLICATION Rajesh Kasiviswanathan, Matthew J. Longley, Sherine S. L. Chan, and William C. Copeland* From the Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 Running Title: Mitochondrial ...
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