نتایج جستجو برای: mitochondrial mediated apoptosis

تعداد نتایج: 643665  

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997
B G Heerdt M A Houston L H Augenlicht

Butyrate, a short-chain fatty acid produced during microbial fermentation of fiber, induces growth arrest, differentiation, and apoptosis of colonic epithelial cells in vitro, and our prior work has shown that this induction is tightly linked to mitochondrial activity. Here we demonstrate that 12 h following induction, SW620 human colonic carcinoma cells accumulate simultaneously in G0-G1 and G...

Journal: :Journal of biomedical optics 2010
Ying-Ying Lu Tong-Sheng Chen Xiao-Ping Wang Li Li

Dihydroartemisinin (DHA), a front-line antimalarial herbal compound, has been shown to possess promising anticancer activity with low toxicity. We have previously reported that DHA induced caspase-3-dependent apoptosis in human lung adenocarcinoma cells. However, the cellular target and molecular mechanism of DHA-induced apoptosis is still poorly defined. We use confocal fluorescence microscopy...

2006
Kim M. McGinnis W. Wang

Changes at the mitochondria are an early, required step in apoptosis in various cell types. We used western blot analysis to demonstrate that the proapoptotic protein Bax translocated from the cytosolic to the mitochondrial fraction in SH-SY5Y human neuroblastoma cells undergoing staurosporineor EGTA-mediated apoptosis. Levels of mitochondrial Bax increased 15 min after staurosporine treatment....

Journal: :Journal of neurochemistry 1999
K M McGinnis M E Gnegy K K Wang

Changes at the mitochondria are an early, required step in apoptosis in various cell types. We used western blot analysis to demonstrate that the proapoptotic protein Bax translocated from the cytosolic to the mitochondrial fraction in SH-SY5Y human neuroblastoma cells undergoing staurosporine- or EGTA-mediated apoptosis. Levels of mitochondrial Bax increased 15 min after staurosporine treatmen...

2015
Zsuzsanna Turi Eniko Hocsak Boglarka Racz Aliz Szabo Andras Balogh Balazs Sumegi Ferenc Gallyas

Previously, we found that the unconventional small human heat-shock protein HSPB11 inhibits cell death by HSP90 mediated cholesterol-rich membrane microdomain dependent activation of phosphatidylinositol-3 kinase/protein kinase B pathway and by stabilising the mitochondrial membrane systems. Also, progressive cytoplasmic expression of HSPB11 correlated with brain tumor malignancy. In the presen...

2017
Yangyang Wang Yong Yuan Xinchun Wang Yanfang Wang Jiang Cheng Li Tian Xinhong Guo Dongmei Qin Wenjiang Cao

BACKGROUND The aim of this study was to investigate the role of tilianin in modulating mitochondrial functions and mitochondria-mediated apoptosis during cardio-protection. MATERIAL AND METHODS Myocardial ischemia/reperfusion (I/R) injury was induced by 30 minutes coronary occlusion followed by two hours reperfusion in Sprague-Dawley rats. To investigate the cardio-protective effects of tiliani...

Journal: :Molecules 2016
Haiyan Ding Rong Han Xueshan Chen Weirong Fang Meng Liu Xuemei Wang Qin Wei Nandani Darshika Kodithuwakku Yunman Li

Mitochondria-mediated cardiomyocyte apoptosis is involved in myocardial ischemia/reperfusion (MI/R) injury. Clematichinenoside (AR) is a triterpenoid saponin isolated from the roots of Clematis chinensis with antioxidant and anti-inflammatory cardioprotection effects against MI/R injury, yet the anti-apoptotic effect and underlying mechanisms of AR in MI/R injury remain unclear. We hypothesize ...

Journal: :Cancer research 2007
Satya Sree N Kolar Rola Barhoumi Joanne R Lupton Robert S Chapkin

We have previously shown that butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis via a nonmitochondrial, Fas-mediated, extrinsic pathway. Interestingly, fermentable fiber when combined with fish oil containing docosahexaenoic acid (DHA, 22:6n-3) exhibits an enhanced ability to induce apoptosis and protect against colon tumorigenesis. To determine the mol...

Journal: :Molecular medicine reports 2016
Ya Chen Meng Li Zhongji Li Peng Gao Xiao Zhou Jianxin Zhang

Bufalin has been shown to induce apoptosis in osteosarcoma cells; however, the underlying mechanism has not been elucidated. The purpose of the present study was to investigate whether mitochondria‑mediated signaling pathways trigger the process of apoptosis in the U‑2OS osteosarcoma cell line. Bufalin inhibited the proliferation and induced apoptosis in U‑2OS cells in a time- and dose‑dependen...

2015
Rama P. Kotipatruni Xuan Ren Dinesh Thotala Jerry J. Jaboin

Aggressive meningiomas exhibit high levels of recurrence, morbidity and mortality. When surgical and radiation options are exhausted, there is need for novel molecularly-targeted therapies. We have recently identified NDRG4 overexpression in aggressive meningiomas. NDRG4 is a member of the N-Myc Downstream Regulated Gene (NDRG) family of the alpha/beta hydrolase superfamily. We have demonstrate...

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