angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...

Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...

Celecoxib, a nonsteroidal anti-inflammatory drug, has been reported to have antitumor and antimetastatic activities, it potential for application in cancer treatments. The expression of matrix metalloproteinase (MMP)-2/9 is strongly correlated with malignancy, inhibition these MMPs believed be effective improving the effects drugs. We previously revealed that UTX-121, which converted sulfonamid...

Highlights . Elevated levels of matrix metalloproteinases 2 and 9 are associated with the initiation severity CHF developed after breast cancer therapy anthracyclines, which may contribute to cardiac remodeling progression systolic dysfunction. Concentrations metalloproteinases-2 -9 in blood serum serve as predictors unfavorable course anthracycline-induced heart failure. Aim To assess role (MM...

conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...

Matrix Metalloproteinases (MMPs), these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues degrading the extracellular matrix (ECM). glycoproteins, gelatin, collagens, proteoglycans elastin are all found ECM. Current meta-analysis confirmed lower levels of IL-6 CRP was following bariatric surgery. Several studies have sh...

Objective. The ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a protein coding gene which associated colorectal cancer other diseases. Therefore, the present study was aimed at investigating effect mechanism of UHRF1 on invasion metastasis in human renal carcinoma cells. Methods. After interfered or overexpressed cell lines A498 769-P, relative mRNA level detected by RT-qPCR immun...