Concerns for potential vulnerability to manganese (Mn) neurotoxicity during fetal and neonatal development have been raised due to increased needs for Mn for normal growth, different sources of exposure to Mn, and pharmacokinetic differences between the young and adults. A physiologically based pharmacokinetic (PBPK) model for Mn during human gestation and lactation was developed to predict Mn ...

The goal of this study was to determine whether Mn-containing superoxide dismutase (MnSOD) gene expression in heart tissue would reflect differences among bioavailabilities of Mn sources earlier than other indices. Broilers were divided into 5 groups and fed a Mn-unsupplemented basal diet (control) or the basal diet supplemented with 120 mg of Mn/kg as Mn sulfate or Mn methionine E (Mn Met E), ...

BACKGROUND & OBJECTIVE To estimate the efficacy of BCG in preventing tuberculosis over a 15-year period, and also to assess the impact of infection with nontuberculous environmental mycobacteria in a rural community in Chingleput district in Tamil Nadu in south India. We re-analysed the 15-year follow up data of a large randomized trial conducted earlier. METHODS A double-blind randomized con...

This study deals with the synthesis and evaluation of salen based derivatives as fire retardants in thermoplastic polyurethane. Salens, hydroxysalens and their first row transition metal complexes (salen-M) were synthesized (Copper, Manganese, Nickel and Zinc). They were then incorporated in thermoplastic polyurethane (TPU) with a loading as low as 10:1 weight ratio. The thermal stability as we...

Mn-doped TiO₂ loaded on wood-based activated carbon fiber (Mn/TiO₂-WACF) was prepared by sol-gel and impregnation method using MnSO₄·H₂O as manganese source. The structure of Mn/TiO₂-WACF was characterized by SEM, XRD, FTIR, N₂ adsorption and UV-Vis, and its photocatalytic activity for methylene blue degradation was investigated. Results show that Mn-doped TiO₂ were loaded on the surface of woo...

Plant species differ in response to high available manganese (Mn), but the mechanisms of sensitivity and tolerance are poorly understood. In solution culture, greater than or equal to 30 µm Mn decreased the growth of soybean (Glycine max), but white lupin (Lupinus albus), narrow-leafed lupin (Lupin angustifolius), and sunflower (Helianthus annuus) grew well at 100 µm Mn. Differences in species'...

Mn was an important alloying element used in Al-Mg-Mn alloys. However, it had to be limited to a low level (<1.0 wt %) to avoid the formation of coarse intermetallics. In order to take full advantage of the benefits of Mn, research was carried out to investigate the possibility of increasing the content of Mn by studying the effect of cooling rate on the formation of Fe- and Mn-rich intermetall...

Manganese (Mn)-induced neurodegenerative toxicity has been associated with a distorted iron (Fe) metabolism at both systemic and cellular levels. In the current study, we examined whether the oxidation states of Mn produced differential effects on certain mitochondrial [Fe-S] containing enzymes in vitro. When mitochondrial aconitase, which possesses a [4Fe-4S] cluster, was incubated with either...