نتایج جستجو برای: modified gurson model gtn

تعداد نتایج: 2310303  

2013

This work is focused on the numerical prediction of the fracture resistance of a flat stiffened panel made of the aluminium alloy 2024 T3 under a monotonic traction condition. The performed numerical simulations have been based on the micromechanical Gurson-Tvergaard (GT) model for ductile damage. The applicability of the GT model to this kind of structural problems has been studied and assesse...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
R Yuan M Sumi L Z Benet

Nitroglycerin (GTN) has been used to treat heart disease for many years. It is generally believed that GTN is a prodrug; however, the mechanism for GTN bioactivation remains unknown. Recent studies, using hepatic microsomes, have suggested the involvement of cytochrome P450 3A (CYP3A) in GTN biotransformation. Here, we used an animal model to test the hypothesis that aortic CYP3A plays a role i...

Journal: :International Journal of Fracture 2023

Abstract This paper presents an experimental and numerical study on quasi-static ductile tearing of thin plates the aluminium alloy AA6016 in three tempers. Depending temper, main fracture mechanism plate tests changes from grain boundary failure to coalescence voids nucleated at constituent particles. The experiments are complemented by nonlinear finite element simulations using enriched Gurso...

Journal: :Mathematical and Computational Applications 2003

Journal: :American journal of physiology. Heart and circulatory physiology 2010
Tommaso Gori Saverio Dragoni Giuseppe Di Stolfo Silvia Sicuro Andrew Liuni Mary Clare Luca George Thomas Matthias Oelze Andreas Daiber John D Parker

Damage and dysfunction of the vascular endothelium critically influence clinical outcomes after ischemia and reperfusion (I/R). Brief exposure to organic nitrates can protect the vascular endothelium from I/R injury via a mechanism that is similar to ischemic preconditioning and is independent of hemodynamic changes. The clinical relevance of these protective effects clearly depends on whether ...

2010
Pierre-Guy Vincent Yann Monerie Pierre Suquet

This study is devoted to the modelling of ductile damage in uranium dioxide. This polycrystalline material contains two populations of voids of well separated size. The problem addressed here is the prediction of the effective flow surface of a Gurson material containing randomly oriented oblate voids. The case of spherical voids is considered first and the variational approach of Gurson is gen...

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