BACKGROUND AND PURPOSE There is little agreement on how to assess outcome in acute stroke trials. Cutoff scores for the Barthel Index (BI) and modified Rankin Scale (mRS) are frequently arbitrarily chosen to dichotomize favorable and unfavorable outcome. We investigated sensitivity and specificity of BI cutoff scores in relation to the mRS to obtain the optimal corresponding BI and mRS scores. ...

Background Historically, trials in acute stroke have largely been unable to show benefit of new interventions. Trials have previously favoured dichotomous analysis of outcome measures employing an ordinal scale, such as the Modified Rankin Scale (mRS). In 2007, the OAST Collaboration showed that preserving the ordinal nature of these scales increased statistical power, recommending the use of o...

background:  the aim of this study was to evaluate whether higher serum levels of igf-i in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of one year follow up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar hospital entered this prospec...

Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results. Methods: We enrolled 118 ischemic stroke patients who were treated ...

BACKGROUND AND PURPOSE The modified Rankin Scale (mRS) is a popular primary stroke outcome measure, but its usefulness is limited by suboptimal reliability (inter-rater agreement). METHODS We developed and tested the reliability of a simplified mRS questionnaire (smRSq) in 50 patients after stroke seen in outpatient clinics. Randomly chosen paired raters administered the smRSq within 20 minut...

OBJECTIVE Our study focused on acute lacunar infarct shapes to explore the risk factors and clinical significance of irregularly shaped lacunar infarctions. METHODS Based on the shape of their acute lacunar infarct, patients (n=204) were classified into the "regular" group or "irregular" group. The characteristics of the lacunar infarction were compared between the regular and irregular group...

background: management of intracranial aneurysms has made debates about the best treatment modality in recent years. the aim of this study was to compare the interventional outcomes between two groups of patients, one treated with endovascular coiling and the other treated with surgical clipping. methods: this prospective study included 48 patients with intracranial aneurysms who underwent endo...

Background and aims There seems to be a U-shaped relation between hemoglobin level ischemic stroke severity. We aimed explore possible causes of this relation. Methods All patients with 2006 2016 admitted within 3 hours onset were included. Hemoglobin NIHSS score obtained on admission. Modified Rankin Scale (mRS) was day 7. Locally weighted scatterplot smoothing (lowess smoother) curves display...

Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission strok...

BACKGROUND AND PURPOSE Basilar artery occlusion has a high mortality rate (85% to 95%) if untreated. We describe a large single-center cohort treated mostly with intravenous alteplase and heparin. METHODS The cohort included 116 patients with angiography-verified basilar artery occlusion. We studied baseline characteristics, frequencies of recanalization and symptomatic intracranial hemorrhag...