The asymmetric unit of the title compound, [Co(C(44)H(28)N(4))]·C(12)H(24)O(6), contains one half of a Co(II)(TPP) (TPP is tetra-phenyl-porphyrin) complex and one half of an 18-crown-6 mol-ecule of crystallization, both lying on inversion centers. The Co(II)(TPP) complex exhibits a nearly planar conformation of the porphyrinate core [maximum deviation = 0.069 (2) Å] with an average Co-N distanc...

OBJECTIVE We investigated the efficacy and safety of the sodium glucose cotransporter 2 inhibitor, empagliflozin, added to multiple daily injections of insulin (MDI insulin) in obese patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Patients inadequately controlled on MDI insulin ± metformin (mean HbA1c 8.3% [67 mmol/mol]; BMI 34.8 kg/m(2); insulin dose 92 internation...

The full mol-ecule of the title compound, C(18)H(18)N(2)O(4), is generated by the application of an inversion centre. There are strong π-π inter-actions between adjacent mol-ecules with a centroid-centroid distance of 3.298 (2)Å.

1 Investigation of cooperativity in the binding of ligands to the D 2 dopamine receptor. Abstract The D 2 dopamine receptor exists as dimers or as higher order oligomers, based on data from physical experiments. In this study we have sought evidence that this oligomerisation leads to cooperativity by examining the binding of three radioligands ([ 3 H]nemonapride, [ 3 H]raclopride, [ 3 H]spipero...

acrjourna understanding of the anatomy and development of fetal and adult hair follicles and the molecular of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries rning the development of basal cell carcinoma (BCC). These studies have shed light on the major f Sonic hedgehog (Shh) signaling and its interactions with the insulin-like growth factor (IGF) a...

The asymmetric unit of the title compound, [Cd2Na2(N3)2(C44H28N4)2(C12H24O6)2], consists of one half of the dimeric complex; the tetra-nuclear mol-ecule lies about an inversion centre. The Cd(II) atom is coordinated by the four pyrrole N atoms of the 5,10,15,20-tetra-phenyl-porphyrinate ligand and one N atom of the axial azide ligand in a square-pyramidal geometry. The azide group is also linke...

In the title complex, [Co(C(18)H(18)N(2)O(4))(C(2)H(3)O(2))(H(2)O)]·2CH(3)OH, the Co(III) atom is hexa-coordinated by water and acetate groups in the axial positions and by the tetra-dentate Schiff base occupying equatorial positions. These axial bonds are longer than the equatorial bonds to the tetra-dentate Schiff base. Two mol-ecules form a dimer through strong hydrogen bonds from the coordi...

The asymmetric unit of the title compound, C(27)H(21)N(7)O(4)S·0.06H(2)O, contains four syndone mol-ecules and a water mol-ecule with a site occupancy of 0.25. In two of the syndone mol-ecules, three atoms in a terminal phenyl ring are disordered over two sets of sites, with occupancy ratios of 0.500 (18):0.500 (18) and 0.512 (17):0.488 (17). The dihedral angles between terminal phenyl rings fo...