نتایج جستجو برای: molecular clock

تعداد نتایج: 666755  

2014
Simon Y. W. Ho Sebastián Duchêne

The molecular clock presents a means of estimating evolutionary rates and timescales using genetic data. These estimates can lead to important insights into evolutionary processes and mechanisms, as well as providing a framework for further biological analyses. In order to deal with rate variation among genes and among lineages, a diverse range of molecular-clock models have been developed. The...

2016
Chi Zhang

This paper provides an overview and a tutorial of molecular clock dating using MrBayes, which is a software for Bayesian inference of phylogeny. Two modern approaches, total-evidence dating and node dating, are demonstrated using a dataset of Hymenoptera with molecular sequences and morphological characters. The similarity and difference of the two methods are compared and discussed. Besides, a...

2015
Weiwei Tao Jing Wu Qian Zhang Shan-Shan Lai Shan Jiang Chen Jiang Ying Xu Bin Xue Jie Du Chao-Jun Li

The mammalian clock system is composed of a master clock and peripheral clocks. At the molecular level, the rhythm-generating mechanism is controlled by a molecular clock composed of positive and negative feedback loops. However, the underlying mechanisms for molecular clock regulation that affect circadian clock function remain unclear. Here, we show that Egr1 (early growth response 1), an ear...

Journal: :Genetics 1987
N Takahata

Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuating substitution rates in time caused by coupled effects of deleterious mutatio...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
F J Ayala

The hypothesis of the molecular evolutionary clock asserts that informational macromolecules (i.e., proteins and nucleic acids) evolve at rates that are constant through time and for different lineages. The clock hypothesis has been extremely powerful for determining evolutionary events of the remote past for which the fossil and other evidence is lacking or insufficient. I review the evolution...

Journal: :Molecular ecology 2008
J T Weir D Schluter

Molecular clocks are widely used to date phylogenetic events, yet evidence supporting the rate constancy of molecular clocks through time and across taxonomic lineages is weak. Here, we present 90 candidate avian clock calibrations obtained from fossils and biogeographical events. Cross-validation techniques were used to identify and discard 16 inconsistent calibration points. Molecular evoluti...

Journal: :Journal of General and Molecular Virology 2020

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