نتایج جستجو برای: molecular subtypes
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PURPOSE To compare the difference between Uygur and Han patients with breast cancer in molecular subtype. METHODS 4 immunohistochemical (IHC) markers (ER, PR, HER-2 and KI-67) were used to divide Uygur and Han breast cancer patients into 4 subtypes (Luminal A, Luminal B, HER-2 over expression and Basal-like), respectively. statistical analysis were used to evaluate difference in molecular sub...
conclusions the prevalence of b. hominis in the study area was lower than that reported for most developed countries, and unlike in other countries in the middle east, st4 was the most prevalent subtype. results blastocystis hominis was found to have a prevalence of 3.33% in the study population. there was no significant association of blastocystis infection with age (p = 0.3) or gender (p = 0....
BACKGROUND Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different muta...
Molecular subtypes and Nottingham Prognostic Index (NPI) are both prognostic models for breast cancer patients. We evaluated the association between molecular subtypes and NPI in 1042 breast cancer patients. The molecular subtypes indicating poorer prognosis were positively correlated to higher NPI (r = 0.138, P = 0.001). ER positive expression and PR high expression were positively correlated ...
background: cryptosporidium is an intestinal protozean parasite causing waterborne and foodborne outbreaks of diarrheal diseases. the present study was performed in order to find prevalence and subtypes of cryptosporidium among children with diarrhea in gonbad kavoos city, northern iran. methods: diarrheic samples were collected from 547 children. the initial parasitological diagnosis was ma...
One of the major challenges faced in defining clinically applicable and homogeneous molecular tumor subtypes is assigning biological and/or clinical interpretations to etiological (intrinsic) subtypes. The conventional approach involves at least three steps: Firstly, identify subtypes using unsupervised clustering of patient tumours with molecular (etiological) profiles; secondly associate the ...
BACKGROUND Breast cancer is a heterogeneous and polygenic disease that can be divided into different molecular subtypes based on histological and genomic features. To date, numerous susceptibility loci of breast cancer have been discovered by genome-wide association studies and may expand the genetic features. However, few loci have been further studied according to molecular subtypes. MATERI...
To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B and basal-like subtypes. The pathological data and prognosis of these subtypes...
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