Single nanoparticle (NP) electrochemical impacts is a rapidly expanding field of fundamental electrochemistry, with applications from electrocatalysis to electroanalysis. These studies, which involve monitoring the electrochemical (usually current–time, I–t) response when a NP from solution impacts with a collector electrode, have the scope to provide considerable information on the properties ...

Using poly(lactide-co-glycolide) (PLGA) particles for drug encapsulation and delivery has recently gained considerable popularity for a number of reasons. An advantage in one sense, but a drawback of PLGA use in another, is that drug delivery systems made of this material can provide a wide range of dissolution profiles, due to their internal structure and properties related to particles' manuf...

This investigation was designed to examine factors involved in the stability of premarital romantic relationships and the extent of emotional distress experienced following their dissolution. During the fall of 1985, a large sample of individuals involved in ongoing dating relationships completed an extensive questionnaire survey. The survey assessed 10 factors: satisfaction with the current pa...

A series of hydrophilic matrix tablets was prepared and tested with respect to their ability to release the hormone melatonin in a controlled manner, in order to alleviate sleep onset and sleep maintenance dysfunctions. Besides the active ingredient, the tablets were comprised of combinations of the following: HPMC K 15M, low viscosity sodium alginate, microcrystalline cellulose (Avicel PH 102)...

We demonstrate a chemical and biological sensing mechanism in microfluidics that transduces chemical and biological signals to electrical signals with large intrinsic amplification without need for complex electronics. The sensing mechanism involves a dissolvable membrane separating a liquid sample chamber from an interdigitated electrode. Dissolution of the membrane (here, a disulfide cross-li...

European Journal of Pharmaceutical Sciences 13 2001 123133 www.elsevier.nllocateejps. Modeling and comparison of dissolution profiles.To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and model independent methods can be used. To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and ...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...

A high density of local natural and human-induced ground deformation 11 structures resulting from the presence of evaporites occur extensively 12 around Zaragoza (NE Spain), posing risks to infrastructures, buildings and 13 agriculture. We studied the potential of a series of interferograms 14 constructed from 29 ERS -1/2 images to detect different types of ground 15 deformation related to evap...