gations: chest x-ray normal; Hb 55%; W.B.C. 7,100 with normal diffierential; iron deficiency on the blood film; E.S.R. 138 mm. in one hour; Paul-Bunnell test negative. Blood culture revealed Haemophilus influenzae type B sensitive to all the usual antibiotics except sulphonamide. This child was treated with ampicillin and made a good recovery. My point in recording this case history is to empha...

Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachyc...

As with many psychiatric drugs, the discovery of irreversible MAOIs was serendipitous. While being used as an antitubercular agent in the 1950s, iproniazid—a derivative of the hydrazine compound isocarboxazid—was observed to have significant antidepressant properties. Almost at the same time as the discovery of TCAs such as amitriptyline and imipramine (which were also discovered by chance), MA...

Abuse of monoamine oxidase inhibitors is not common but there are a few cases of addiction in the literature. Most of these patients had an additional diagnosis, either history of past drug abuse or personality disorder and MAOI withdrawal symptoms have been reported. We encountered three patients who received MAOI under psychiatric care. They were all self medicated by increasing the doses on ...

MAN MAO-QIANG, KENNETH R. FEINGOLD, FUSHENG WANG, CARL R. THORNFELDT, and PETER M. ELIAS, Dermatology and Medicine Services, Veterans Administration Medical Center, San Francisco, CA 94121 (M.M-Q., K.R.F., P.M.E.); Departments of Dermatology (M.M-Q., K.R.F., P. M. E. ) and Medicine (t•. if. t • . ), University of California School of Medicine, San Francisco, CA; Department ofDermatology, Yuhuan...

Historically, much of the focus on monoamine oxidases and their substrates has been in the area of depression and the monoamine neurotransmitters serotonin (5-hydroxytryptamine), noradrenaline, and to a lesser extent, dopamine. With both forms of monoamine oxidase (A and B), the production of hydrogen peroxide as a byproduct of the reaction between the monoamine oxidases and their monoamine sub...

10.2217/14750708.5.2.203 © 2 Parkinson’s disease is a neurodegenerative disorder manifested by a combination of motor and non-motor symptoms. Levodopa, a dopamine precursor, is the most efficacious drug available to control the symptoms of Parkinson’s disease. Almost all other medications with symptomatic benefit for Parkinson’s disease show their effect by facilitating the dopaminergic system,...