نتایج جستجو برای: monozygotic twins
تعداد نتایج: 14593 فیلتر نتایج به سال:
This study investigates the validity of retrospective determination of chorion type by asking the question to the mother about the number of placentas. In the "East Flanders Prospective Twin Survey" (EFPTS), accurate information on the placentation and zygosity of the multiples was collected prospectively. The mothers of 231 monozygotic (95 dichorionic and 136 monochorionic) twins and 255 dizyg...
Monozygotic (identical) twins have been widely used in genetic studies to determine the relative contributions of heredity and the environment in human diseases. Discordance in disease manifestation between affected monozygotic twins has been attributed to either environmental factors or different patterns of X chromosome inactivation (XCI). However, recent studies have identified genetic and e...
Unilateral atresia is an extremely uncommon congenital disorder in monozygotic twins. We present the first case in the literature of premature, monozygotic twins with no other congenital genetic defects other than only one twin with unilateral choanal atresia on the right side, being the other sibling completely normal. Diagnostic examinations performed to both twins consisted of nasal endoscop...
Although members of monozygotic twin pairs are identical in genome sequence, they may differ in patterns of gene expression. One early and irreversible process affecting gene expression, which can create differences within pairs of female monozygotic twins, is X inactivation - one twin can express mainly paternally-received genes on the X chromosome while the other twin expresses mainly materna...
OBJECTIVE To test the validity of the fetal origins hypothesis and the classic twin method. DESIGN Follow up study of pairs of same sex twins in which both twins survived to age 6. SETTING Denmark. SUBJECTS 8495 twin individuals born 1870-1900, followed through to 31 December 1991. MAIN OUTCOME MEASURES Mortality calculated on a cohort basis. RESULTS Mortality among twins and the gene...
To the Editor: We found the study of clinical responses to opioids by Angst et al.1 to be an excellent first-of-its-kind study for distinguishing the contribution of heredity versus environment. Much work has been done using twins to separate heredity from environment and this addition to our literature is timely. Although the use of twins to separate nature from nurture is a long-established m...
Evidence for genetic factors explaining the birth weight-blood pressure relation. Analysis in twins.
Epidemiological studies have consistently shown an inverse association between birth weight and systolic blood pressure in later life after adjustment for current size. To examine whether this association is explained by intrauterine or genetic factors, we investigated birth weight and blood pressure data in 53 dizygotic and 61 monozygotic adolescent twin pairs. Birth weight was obtained from t...
Goldenhar syndrome is a rare developmental disorder characterised by hemifacial microsomia, epibulbar tumours, ear malformation, and vertebral anomalies. As monozygotic (MZ) twins are believed to be genetically identical, discordance for disease phenotype between MZ twins varies with craniofacial anomalies, cardiac, vertebral, and central nervous system defects sporadically. We report a case of...
By running the Swedish twin registry containing about 25,000 pairs of twins of the same sex together with the central national diagnosis register of hospital inpatients, 80 twin pairs suffering from inflammatory bowel disease were found. In the ulcerative colitis group one of 16 monozygotic pairs was concordant for the disease, but all the other 20 pairs (dizygotic or unknown zygosity) were dis...
Common knowledge of over a century has it that monozygotic and dizygotic twinning events occur by unrelated mechanisms: monozygotic twinning 'splits' embryos, producing anomalously re-arranged embryogenic asymmetries; dizygotic twinning begins with independent ovulations yielding undisturbed parallel embryogeneses with no expectation of departures from singleton outcomes. The anomalies statisti...
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