interleukin (il)-25, a cytokine of il-17 family, can activate p38 mitogen-activated protein kinases(mapk) and nuclear factor(nf)-κb pathways to propagate th2 responses. the allergic rhinitis mouse model was established by stimulating balb/c mouse with ovalbumin (ova). then we detected expression of il-25 and downstream p38mapk and nf-κb. the expression of il-25, p38mapk and nf-κb were detected ...

If you study a human disease, it is likely that you have tried to generate a mouse model. Sometimes, these models are excellent; others are disappointing. Or, so we think. How often does our mouse mutant not model the human disease because of limitations in how we may look at it? In any living organism, many factors work together to produce the phenotype. Here, new phenotyping paradigms for ass...

conclusions it seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury. results the result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules i...

previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...

Background: C5areceptor antagonistPMX205 is a synthetic hexapeptidecapable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a myriad inflammation models. The anti-inflammatory effect of PMX205 on periodontitis is yet to be fully fathomed. Objective: To examine the anti-inflammatory effec...