This paper introduces L2F’s (INESC-ID) question/answering system and presents its results in the QA@CLEF07 evaluation task. QA@LF bases its performance on a high-quality deep linguistic analysis of the question, which is strongly based on named entity recognition. However, if a precise analysis is not possible or if no answer is found in previous processed data, the system is also capable of re...

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG trinucleotide repeat sequence in the huntingtin gene. The resulting poly-glutamine expansion in the huntingtin protein imparts a novel toxic gain of function causing selective loss of medium spiny neurons (MSNs) in the striatum. Although the exact mechanism of cell death is unclear, recent evidence s...

background iran has a widespread diagnostics and clinical support services (dcss) network that plays a crucial role in providing diagnostic and clinical support services to both inpatient and outpatient care. however, very little is known on the application of quality assurance (qa) policies in dcss units. this study explores the extent of application of eleven qa strategies in dcss units withi...

INTRODUCTION HLA-G is a major histocompatibility complex (MHC), class Ib molecule that is selectively expressed at the fetal-maternal interface. It is thought to play a role in protecting the fetus from the maternal immune response. Interestingly, the preimplantation embryo development (Ped) gene product Qa-2 is also a mouse MHC class Ib protein that affects cleavage and division of preimplanta...

H-2 gene products are of central importance in immune recognition, and account for the strong transplantation resistance observed between mouse strains. Murine embryonal carcinomo (EC) cells are the tumourigenic stem cells of teratocarcinomas, and they elicit strong transplantation resistance in some allogeneic mouse strains (1) but do not express H-2 antigens. Since it is generally believed th...

An ensemble of genetic networks that describe how the model fungal system, Neurospora crassa, utilizes quinic acid (QA) as a sole carbon source has been identified previously. A genetic network for QA metabolism involves the genes, qa-1F and qa-1S, that encode a transcriptional activator and repressor, respectively and structural genes, qa-2, qa-3, qa-4, qa-x, and qa-y. By a series of 4 separat...

The qa-1 regulatory region controls the expression of the three structural genes required for the early reactions in quinic acid catabolism in Neurospora crassa. Genetic analysis previously identified two types of noninducible qa-1 mutants, qa-1S and qa-1F, which mapped in separate non-overlapping regions. These mutations were originally interpreted as defining separate domains of a single regu...

Gene replacement by transformation, employing selective genetic recombination techniques, has been used to delete or disrupt the qa-x, qa-y and qa-1S genes of the qa gene cluster of Neurospora crassa. The growth characteristics of the strain carrying the deletion of the qa-y gene support earlier evidence that this gene encodes a quinic acid permease. The strain containing the deletion of the qa...