OBJECTIVES To compare extracellular and intracellular activities of telavancin (versus vancomycin) against Staphylococcus aureus (MSSA, MRSA, VISA and VRSA). METHODS Determination of cfu changes (3-24 h) in culture medium and in macrophages at concentrations ranging from 0.01 to 1000x MIC. RESULTS Extracellularly, telavancin displayed a fast, concentration-dependent bactericidal activity ag...

Abstract Background The 2019 American Thoracic Society/Infectious Diseases Society of America guidelines for community-acquired pneumonia (CAP) revised recommendations culturing and empiric broad-spectrum antibiotics. We simulated guideline adoption in Veterans Affairs (VA) inpatients. Methods For all VA acute hospitalizations CAP from 2006–2016 nationwide, we compared observed with guideline-e...

Background and objectives: Methicillin-resistant Staphylococcus aureus (MRSA) has resulted in a worldwide threat due to the virulence and broad distribution in the hospital and community. Novel antibiotics are required to combat the emergence of multidrug-resistant bacteria such as MRSA. In the present study, the antibacterial activity of Trachyspermum ammi es...

Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major problem, causing severe and intractable infections worldwide. MRSA is resistant to all beta-lactam antibiotics, and alternative treatments are limited. A very limited number of new antibiotics have been discovered over the last half-century, novel agents for the treatment of MRSA infections are urgently needed. Marinopyr...

Infections caused by drug-resistant pathogens are on the rise. The ongoing spread of methicillin-resistant Staphylococcus aureus (MRSA) strains exemplifies the urgent need for new antibiotics. The marine natural product, marinopyrrole A, was previously shown to have potent antibiotic activity against Gram-positive pathogens, including MRSA. However, its minimum inhibitory concentration (MIC) ag...

A wide variety of antimicrobial cationic agents, such as chlorhexidine gluconate, are commonly used in antiseptic preparations in the prevention of nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In this study was investigated the activity of chlorhexidine gluconate against MRSA and methicillin-sensitive Staphylococcus aureus (MSSA). The quantitative suspensi...

Dalbavancin is a lipoglycopeptide antibiotic recently approved by the United States Food and Drug Administration (FDA) for acute bacterial skin and skin structure infections (ABSSSIs). It is active against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), and minimum inhibitory concentrations (MICs) are consistently <0.125 µg/ml, much lower than most other a...

This novel study investigated the loading of mupirocin nanoparticles into a hydrogel which was expected to enhance antibacterial activity mupirocin. The inhibition isoleucyl-tRNA synthetase and global gene expression in methicillin-resistant Staphylococcus aureus (MRSA) by nanoparticle-loaded (MLH) pure compared. MLH rapidly inhibited growth bacterial populations after 1 h treatment. At 12 h, M...

BACKGROUND The increasing resistance of Staphylococcus aureus to conventional antibiotics poses a major health problem. Moreover, S. aureus can survive within phagocytes, thus evading some antibiotics and the innate immune response. Rhodomyrtone, a bioactive compound from the leaves of Rhodomyrtus tomentosa, possesses potent antibacterial activity against methicillin-resistant S. aureus (MRSA)....

Methicillin-resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay...