Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide, carries a poor prognosis. The healthcare costs of DRMM have not previously been reported. We analyzed detailed medical resource utilization (MRU) costs, drug costs and outcomes for 39 UK patients receiving standard DRMM therapy. Median OS in this cohort was 5.6 months...

This paper studies a fundamental algorithmic problem related to the design of demand-aware networks: networks whose topologies adjust toward traffic patterns they serve, in an online manner. The goal is strike tradeoff between benefits such adjustments (shorter routes) and their costs (reconfigurations). In particular, we consider designing self-adjusting tree network which serves single-source...

Relational knowledge is a hallmark of human cognition and the subject of a vast body of research. In this paper we argue that existing accounts of relations are inadequate because they have little to say about how relations arise in the rst place and because they tend to be limited to particular sorts of relational tasks. We present a new approach to the learning and representation of relations...

It is true that some conventional algorithms do not fit in Continuous Media (CM) environments because of their different properties. A typical example is the buffer replacement algorithmssuch as least recently used (LRU) and most recently used (MRU) strategies. These replacement policies are based on the referencing history for replacing buffered page with lower priority because it is not alway...

The Microsoft Windows registry is an important resource in digital forensic investigations. It contains information about operating system configuration, installed software and user activity. Several researchers have focused on the forensic analysis of the Windows registry, but a robust method for associating past events with registry data values extracted from Windows restore points is not yet...

Status of This Memo This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. As of this writing, no current IEEE standard supports the use of "jumbo frames" (MTU greater than 1500). Although this document contains recommended mechanisms to detect problems in the path, interoperability and reliability...

O objetivo deste trabalho é propor uma nova prática pedagógica de ensino, com a finalidade buscar um maior interesse dos alunos pelo ensino ciências, principalmente em Física. consiste algumas etapas, realizações experimentos utilizando protótipo experimental chamado Análise do Movimento Móvel Usando o Trilho Ar e Placa Arduino como Aquisição Dados. uitiliza sensores LDR conectados à placa faze...

In this paper, an indoor robot navigation system is investigated, where intelligent reflecting surface (IRS) employed to enhance the connectivity between access point (AP) and robotic users. Both single-user multiple-user scenarios are considered. scenario, one mobile user (MRU) communicates with AP. AP serves MRU static (SRU) employing either non-orthogonal multiple (NOMA) or orthogonal (OMA) ...

UNLABELLED The significance of delayed tissue tracer transit (TTT) of (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3) has not been systematically evaluated in hydronephrosis. We sought to demonstrate that delayed TTT accompanies both functional decline and histomorphologic restructuring. METHODS Twenty 2- to 3-mo-old piglets with surgically induced partial unilateral ureteral stenosis were ex...