Metadynamics (MTD) is a very powerful technique to sample high-dimensional free energy landscapes, and due to its self-guiding property, the method has been successful in studying complex reactions and conformational changes. MTD sampling is based on filling the free energy basins by biasing potentials and thus for cases with flat, broad, and unbound free energy wells, the computational time to...

A Moving Target Defense (MTD)-enabled system is one which can dynamically and rapidly change its properties and code such that the attackers do not have sufficient time to exploit it. Although a variety of MTD systems have been proposed, fewwork has focused on assessing the relative cost-effectiveness of differentMTD approaches. In this paper, based on a generic MTD theory, we propose five gene...

In this study, we describe a Drosophila melanogaster transposon insertion mutant with tolerance to Vibrio cholerae infection and markedly decreased transcription of diptericin as well as other genes regulated by the immune deficiency innate immunity signaling pathway. We present genetic evidence that this insertion affects a locus previously implicated in pupal eclosion. This genetic locus, whi...

Transverse maxillomandibular discrepancies are a major component of several malocclusions. Orthopedic and orthodontic forces are used routinely to correct a maxillary transverse deficiency (MTD) in a young patient. Correction of MTD in a skeletally mature patient is more challenging because of changes in the osseous articulations of the maxilla with the adjoining bones. Surgically assisted rapi...

Convex Polyhedra S. A. Cameron R. K. Culley McDonnell Douglas Research Laboratories Arti cial Intelligence Technology Group St. Louis, MO, USA 63166 Abstract Given two objects we de ne the minimal translational distance (MTD) between them to be the length of the shortest relative translation that results in the objects being in contact. MTD is equivalent to the distance between two objects if t...

We study moving-target defense (MTD) that actively perturbs transmission line reactances to thwart stealthy false data injection (FDI) attacks against state estimation in a power grid. Prior work on this topic has proposed MTD based on randomly selected reactance perturbations, but these perturbations cannot guarantee effective attack detection. To address the issue, we present formal design cr...

We have used representational difference analysis (RDA) applied to cDNA to isolate transcripts regulated by MEC-3, a transcription factor needed for the differentiation of the six touch receptor neurons in Caenorhabditis elegans. Six percent of 595 cDNAs isolated by cDNA RDA were mec-3-dependent. These cDNAs represented mRNA from two previously known genes, mec-18 and mec-7, and one new gene, m...

Introduction: Use of patient-based voice assessment scales is an appropriate method that is frequently used to demonstrate effectiveness of voice therapy. This study was aimed at determining the effectiveness ofvoice therapy among patients with secondary muscle tension dysphonia (MTD) and vocal mass lesions.   Materials and Methods: The study design was prospective, with within-participant repe...

Anethum graveolens L. (dill) is used widely in Asian food and folk medicine but its safety profile for further clinical studies has remained unclear. After administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. Doses up to 2000 mg/kg in acute...

The chemopreventive action of 40 and 80% maximum tolerated dose (MTD) levels of piroxicam, D,L-alpha-difluoromethylornithine (DMFO), 16 alpha-fluoro-5-androsten-17-one (DHEA analogue 8354), and ellagic acid (EA) administered in diet individually and in combination before and during initiation and postinitiation phases of azoxymethane-induced neoplasia of the intestine was studied in male F344 r...