N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly s...

The cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl dihalide was investigated by using comminuted potassium carbonate as a base and toluene as a solvent in the presence of hexadecyltrimethylammonium bromide (HTMAB) as a phase-transfer catalyst, which provided a conventional procedure with the advantage of short reaction period and high product yield. The factors influencin...

zrp2o7 nanoparticles (nps) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. using this method we obtained low reaction times, easy isolation of the targeted molecules, e...

Small molecules with dithieno[3,2-b;2',3'-d]thiophene as central building block and octyl cyanoacetate and octyl cyanoacetamide as different terminal building blocks have been designed and synthesized. The amide containing small molecule can form intermolecular hydrogen bonding between N-H...O = C of the amide group. The photovoltaic properties and active layer morphologies of the two molecules...

A series of novel monoazo-disperse dyes containing pyrazolo[1,5-a]pyrimidine structures were synthesized starting with the coupling reaction between ethyl cyanoacetate and 4-hydroxybenzenediazonium chloride, followed by treatment of the resulting hydrazone product with hydrazine hydrate. The pyrazolohydrazone 6 is then treated with either 2,4-pentandione and enaminonitrile or aryl-substituted e...

The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2'-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomethylisoquinolinium chloride mainly gave complex indolo[2″,3″:2',3']pyrrolo[3',4':4,5]pyrrolo[2,1-a...

ZrP2O7 nanoparticles (NPs) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. Using this method we obtained low reaction times, easy isolation of the targeted molecules, e...

the cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl dihalide was investigated by using comminuted potassium carbonate as a base and toluene as a solvent in the presence of hexadecyltrimethylammonium bromide (htmab) as a phase-transfer catalyst, which provided a conventional procedure with the advantage of short reaction period and high product yield. the factors influencin...