Mammalian target of rapamycin (mTOR) has an important role in various biological processes in cells. In the present study, we investigated temporal changes in mTOR and phosphorylated-mTOR (p-mTOR) expressions in the rat hippocampal CA1 region following chronic cerebral hypoperfusion (CCH) induced by permanent bilateral common carotid arteries occlusion (2VO). The mTOR immunoreactivity in the py...

mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors. Here, we identify a member of this pathway, a protein named GbetaL that binds to the kinase domain of mTOR and stabilizes the interaction of raptor with mTOR. Like mTOR and raptor, GbetaL participates in nutrient- and growth factor-mediated signaling to S6K1, a...

OBJECTIVES The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). However, the association between mTOR/p-mTOR expression and NSCLC patients' prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSC...

Purpose:mTOR is a validated target in cancer. It remains to be determined whether melanoma patients bearingmTORmutation could be selected for treatment with PI3K–AKT–mTOR pathway inhibitors. Experimental Design: A total of 412 melanoma samples were included. Gene aberrations in all exons ofmTORwere detected by Sanger sequencing and confirmed by using Agilent's SureSelect Target Enrichment Syste...

Biochemical and genetic mechanisms of oxidative stress (OS) developing in blood patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty T2DM 10 healthy persons participated this study. Lipid peroxidation, the content protein carbonyls H2O2 production measured plasma erythrocytes as OS biomarkers. Activity SOD, catalase, GPx well reduced glutathionе (GSH) level estimated. The gene exp...

El cáncer es una causa importante de morbilidad y mortalidad en los receptores trasplante. La combinación infecciones virales, terapia inmunosupresión la alteración el sistema inmune pacientes trasplantados, contribuyen al desarrollo cáncer. sarcoma Kaposi causado por virus herpes humano 8 (VHH-8), aunque raro población general, puede ser hasta 300 veces más frecuente con trasplante renal. diag...

Cellular senescence is an important part of the aging process and forms basis age-related diseases. In our study, we discussed relationship between mammalian target rapamycin (mTOR) signaling pathway polyphenols that affect this cellular senescence. For this, determined keywords 'mTOR' or 'polyphenol' 'cellular aging'. We searched these in scientific databases such as Scopus, Institute for Scie...

AIMS The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) occurring downstream in the PI3K/Akt/mTOR pathway, are regarded as potential prognostic markers for gastric cancer (GC). However, the prognostic value of mTOR/p-mTOR expression remains controversial. In this study, we determined the expression of mTOR, p-mTOR, p70S6k, and p-p70S6K in GC, and investigated the correlat...

Molecular targeted therapies against KRAS mutant pancreatic ductal adenocarcinoma (PDAC) remain insufficient. The most serious causes are supposed to be bypass activation of the PI3K/AKT/mTOR signaling pathway and crosstalk between mTOR hypoxia inducible factor (HIF). This short review is aimed at clarifying involvement activated translation HIF-1α mRNA in oncogenesis PDAC association with CA9 ...

Mammalian target of rapamycin (mTOR) is an evolutionally conserved serine/threonine kinase that integrates signals from multiple pathways, including nutrients (e.g., amino acids and glucose), growth factors (e.g., insulin and insulinlike growth factor 1), hormones (e.g., leptin), and stresses (e.g., starvation, hypoxia, and DNA damage) to regulate a wide variety of eukaryotic cellular functions...