Dr. Leopoldo Di Iorio: On the basis of this clinical presentation, four main hypotheses were considered and simultaneously investigated. First, a cardiogenic shock was considered (subjects with Down’s syndrome can often have multiple cardiac abnormalities, such as atrium-ventricular channel, ventricular or atrial defects, Fallot’s tetralogy), but echocardiography excluded significant alteration...

Toxic Epidermal Necrolysis (TEN) is a rare and often fatal muco-cutaneous disease usually related to severe adverse drug reaction. The standard treatment of TEN remains controversial and to our knowledge, all reports in literature are mostly concentrated on systemic therapy. On the contrary, no report deals with deep skin scars that may occur. We therefore present an original case of a severe s...

Pemphigus Vulgaris (PV) has one of the strongest known HLA disease associations. The majority PV patients studied carry either DRB1*0402 or DQB1*0503. However, studies on associations in have largely focused populations with specific ethnic backgrounds, often Ashkenazi Jewish (AJ) and non-Jewish Caucasians there are limited African descent. We investigated status 11 American (AA) comparison to ...

more than 90% of patients infected with cutaneous leishmaniasis live in afghanistan, the middle east, algeria, brazil, and peru. cutaneous leishmaniasis in iran is caused by leishmania tropica and leishmania major . most skin lesions evolve from papular to nodular, to ulcerative form with a central depression surrounded by a raised indurate border. some lesions persist as nodules or plaques. mu...

Angiokeratoma is a rare, usually acquired muco-cutaneous wart-like vascular lesion that is frequently reported in the scrotum. Bleeding may occur if angiokeratoma is excoriated or traumatized. We report an exceedingly rare solitary eyelid angiokeratoma in an otherwise normal middle aged male. Our case represents the second case in the English peer reviewed literature since 1966, when the first ...

Leishmaniasis is the general denomination given to the infection caused by any species of the Leishmania protozoan genus transmitted in Europe, Asia and Africa by sand flies (Phlebotomus) and by species of Lutzomyia in America. It is endemic to the Mediterranean basin and its incidence has increased in recent years in connection with immunodepression status. It gives rise to 4 clinical syndrome...

More than 90% of patients infected with cutaneous leishmaniasis live in Afghanistan, the Middle East, Algeria, Brazil, and Peru. Cutaneous leishmaniasis in Iran is caused by Leishmania tropica and Leishmania major. Most skin lesions evolve from papular to nodular, to ulcerative form with a central depression surrounded by a raised indurate border. Some lesions persist as nodules or plaques. Mul...

Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory muco-cutaneous disease classified among the potentially malignant lesions of oral mucosa. In this study we evaluated tissue expression of p53، ki-67 in OLP compared to normal oral mucosa. Methods: Specimens (formalin-fixed and paraffinembedded) of 44 lesions of OLP and 30 controls referred to immunohistochemistry (...