نتایج جستجو برای: multi cyclin dependentkinase inhibitors
تعداد نتایج: 670555 فیلتر نتایج به سال:
6. Dolcetti R, Doglioni C, Maestro R et al. P53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: Genetic and prognostic implications. Int J Cancer 1992; 52(2): 178-1 82. 7. Calitano J, van der Riet P, Westra W at al. Genetic progression model forhead and neck cancer: Implications for field cancerization. Cancer Res 1996; 56: 2488-2492. 8. El-D...
Synthesis and Biological Evaluation of 3-Aryl Pyrazoles as CDK2/HDAC Inhibitor for Anticancer Agents
s: A novel series of pyrazole derivatives containing hydroxamic acid group were designed and synthesized as multi-target inhibitors targeting CDK2 (cyclin-dependent kinases 2) and HDAC (histone deacetylase). Compounds 6e and 6f exhibited most potent CDK2 inhibition as well as HDAC inhibition. In vitro antiproliferative assay indicated that several compounds showed better antiproliferative poten...
the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...
The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Src inhibitors increase cellular p27 stability, and Src overexpression accelerates p27 proteolysis. Src-phosphorylated p27 is shown to inhibit cyclin E-Cdk2 poorly in vitro, and Src t...
Cyclin 4/6 inhibitors (CDKIs) are currently used in patients with hormone-dependent breast cancer as first-line treatment for metastatic disease. One of their less frequent but equally limiting adverse events is skin toxicity. The purpose the study was to report incidence toxicity treated CDKIs our center. Between November 2017 and December 2022, information from affected (MBC) at Hospital del ...
Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine and for expressed HH pathway-regulated species in a linked genetic...
Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors. In the present study, we examined whether gefitinib- and erlotinib-induced lung injury related to ILD through endoplasmic reticulum (ER) stress, which is a causative int...
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