Morpholinium hydrogen Sulphate as Brønsted acidic ionic liquid was used as an efficient and reusable catalyst for the onepot synthesis of 2,4,5-trisubstituted imidazoles that achieved by three component cyclocondensation of 1,2-dicarbonyl compound, aromatic or aliphatic aldehyde and ammonium acetate under thermal solvent-free conditions. The key advantages of this process are cost effectiveness...

Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications.The development of multicomponent reactions designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. in this Manuscript, a facile and efficient multicomponent synthesis of functional...

substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. the synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. this intermediate immediately undergoes ring closure and oxidative aromatization. the reaction is catalyzed by natural kaolin, a st...

6-Hydroxy-2-oxo-2H-chromene-4-carbaldehyde (2), 6-chloro-2-oxo-2H-chromene-4-carbaldehyde (3) and 6-hydrazinyl-4-methyl-2H-chromen-2-one (5) were prepared as single-pharmacophore motif key intermediates. Compounds 2, 3 and 5 were incorporated in a series of multicomponent reactions (MCRs), under microwave assistance as well as conventional chemical synthesis processes, to afford a series of thr...

A facile and novel synthesis of thirteen 2-amino-3-cyanopyridine derivatives 5(a–m) by a one-pot multicomponent reactions (MCRs) is described for the first time, starting from aromatic aldehydes, malononitrile, methyl ketones, or cyclohexanone ammonium acetate in presence nanostructured diphosphate Na2CaP2O7 (DIPH) at 80 °C under solvent-free conditions. These compounds were brought into existe...

BACKGROUND AND OBJECTIVES Multiple chromosome rearrangements (MCRs) are found in 5-10% of newly diagnosed patients with acute myeloid leukemia (AML) and 15-30% of patients with myelodysplastic syndromes (MDS). However, the initial causes of MCRs and the molecular mechanisms involved are largely unresolved. Nor are the karyotypic patterns well studied, mainly because of the difficulties of obtai...

This paper investigates prices of consumer electronics sold on the Web by both onlineonly retailers (Dotcoms) and the online branches of multi-channel retailers (MCRs). Surprisingly, we find that Dotcoms charge higher price than MCRs, a conclusion contradictory to the results of most of empirical studies. We also find that the electronics prices decreased over the period of study in general, dr...

During the last few decades, Multi-Component Reactions (MCRs) have been studied as a facile route to assemble complex important structures in a small number of steps, while reducing production costs and environmental concerns. As a result, MCRs have attracted growing attention, leading to the development of new, highly selective methods for the synthesis of bioactive compounds such as natural p...

an efficient and green method for the synthesis of pyrano[3,2-c]chromene or pyrano[4,3-b]pyrone derivatives is described by using a three-component condensation process of malononitrile, aldehyde, and 4-hydroxycoumarine or 4-hydroxypyrone in [bmim]bf4-licl as an ionic liquid.