Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. Materials & Methods: ...

We describe a case of 68-year-old Japanese man with HIV-1 infection who developed acute kidney injury with prominent tubular dysfunction immediately after starting tenofovir-containing antiretroviral therapy. Antiretroviral therapy was discontinued in two weeks but renal function, as well as tubular function, did not shown full recovery even at a 3-year follow-up examination. Acute tubular necr...

Acute interstitial nephritis is a rare complication of tetracycline therapy and there have been two case reports associated with minocycline [1,2]. In both cases the patients presented within 2 weeks of commencing the antibiotic with an acute febrile illness and loin pain, and an acute interstitial nephritis was confirmed on renal biopsy. We report a case of chronic interstitial nephritis in a ...

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and prote...

Acute interstitial nephritis is a common cause of acute kidney injury. Acute interstitial nephritis is most commonly induced by drug although the cause may also be infective, autoimmune, or idiopathic. Although eosinophilia and eosinophiluria may help identify this disease entity, the gold standard for diagnosis remains renal biopsy. Prompt diagnosis is important because discontinuation of the ...

paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, in this study, paraquat (pq)-induced changes in the expression of cyclooxygenase-2 (cox-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. twenty four male wistar rats (180-200 g) were exposed either against saline as control group or var...

OBJECTIVE To describe a patient who developed acute interstitial nephritis, hepatitis and serum sickness-like syndrome after receiving piperacillin-tazobactam (zosyn) therapy. CASE SUMMARY A 30-year-old woman received a 7-day course of piperacillin-tazobactam as empiric treatment for pneumonia. The patient's kidney function worsened and she turned anuric needing dialysis. She also developed f...

The magnitude of the suspected increase in risk of acute interstitial nephritis among proton pump inhibitor users is uncertain. Here, we conducted a nested case-control study using routinely collected national health and drug dispensing data in New Zealand to estimate the relative and absolute risks of acute interstitial nephritis resulting in hospitalization or death in users of proton pump in...

Cellular and fluid exudation in the interstitial tissue was noted by Councilman in 1898, while he studied kidneys of patients who died of scarlet fever and diphtheria (1). Councilman also determined that these kidneys did not contain bacteria (they were sterile). He called the condition acute interstitial nephritis (AIN). The term interstitial nephritis connotes predominant involvement of the r...

Key words: interstitial nephritis; retinitis pigmentosa; Renal histology revealed chronic tubulointerstitial nephritis with a diÂuse interstitial cellular infiltrate Bardet–Biedl syndrome. consisting mainly of lymphocytes and plasma cells. There were 41 glomeruli, of which 29 were sclerosed. Immunofluorescence was negative. Electron-micro