The potential of statins as antimicrobials has been recognized for more than a decade; unfortunately, minimal progress in exploring this promise. This mini review highlights the structure and their relevance antimicrobial co-drug. current information on inhibition mechanism bacterial, fungal, viral, biofilms is also described.

Fanconi anemia (FA) is characterized by bone marrow failure, clonal evolution to myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML), and epithelial malignancies and is caused by bi-allelic or X-linked inactivation of 1 of 15 different genes, including FANCP/SLX4.2 Eight of the gene products (FANCA, -B, -C, -E, -F, -G, -L, and -M) form a nuclear “core” complex that must be intac...

A titanocene-catalyzed multicomponent coupling to provide diarylethynyl methanes is described. By combining the multifunctionality of Cp(2)TiCl(2) with the traceless dielectrophilicity of aryl aldehydes, all-carbon tertiary centers are obtained in 55-99% yield.

Changing and competing land use, where we make use of a growing share of resources, potentially undermines the capacity of forests to provide multiple functions such as timber, biodiversity, recreation and pasture lands. The governance challenge is thus to manage trade-offs between human needs and, at the same time, maintain the capacities of forests to provide us with these needs. Sweden provi...

Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo assembly-disassembly from inner membrane pilin subunits and exhibit astonishing multifunctionality. Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-resistant human pathogens, yet detailed structures are unavailable for any T4P. Here, we dete...

This paper addresses the following questions: (1) Is it true, as is often claimed, that utterances in dialogue tend to have multiple functions? (2) If so, then what are the reasons for that? (3) How many functions does a dialogue utterance typically have, and which factors determine this? (4) What consequences does this have for the computational semantics of dialogue utterances? Answers to the...