نتایج جستجو برای: myc

تعداد نتایج: 16295  

Journal: :Journal of Case Reports and Images in Oncology 2023

Triple hit lymphomas (THL) comprise a rare, heterogenous group of and like many B-cell lymphomas, chromosomal translocations are biologic diagnostic hallmarks disease. Traditionally referred to as subset double (DHL) in literature, THLs characteristically involve rearrangements c-MYC, BCL-2, BCL-6 oncogenes. Many case series high-grade lymphoma, especially MYC/BCL2 have been described the but r...

2006
Irene Slave Richard Ellenbogen Woo-Hee Jung Gordon F. Vawter Cynthia Kretschmar Bruce R. Korf

Although N-myc amplification in neuroblastomas correlates with poor prognosis, not all neuroblastomas which fail to respond to therapy have N-myc amplification. To determine whether other modes of myc gene activation underlie progression of some neuroblastomas, 45 were analyzed for amplification of N-wiyc, c-myc and L-myc and 26 were studied for transcription of these oncogenes. N-myc amplifica...

Journal: :Hematological Oncology 2021

Introduction: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) are aggressive tumors poor prognosis. In virtually all HGBL-DH/TH-BCL2 tumors, is rearranged to the variable region of IGH locus, which thought occur early in differentiation during RAG-mediated VDJ recombination, leading constitutive overexpression driven by potent Eµ enhancer. We explored topolo...

Journal: :Molecular and cellular biology 2000
M A Gregory S R Hann

The c-Myc oncoprotein is a transcription factor which is a critical regulator of cellular proliferation. Deregulated expression of c-Myc is associated with many human cancers, including Burkitt's lymphoma. The c-Myc protein is normally degraded very rapidly with a half-life of 20 to 30 min. Here we demonstrate that proteolysis of c-Myc in vivo is mediated by the ubiquitin-proteasome pathway. In...

Journal: :Cell Death and Disease 2021

Abstract In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify complicated crosstalk of Annexin A2 (ANXA2) with Glypican 1 (GPC1) demonstrate whether combined indexes ANXA2 GPC1 could improve prognostic evaluation patients. We found that ANXA2-induced cell proliferation c-Myc-dependent manner. increased expression via c-Myc upregulated ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
David N Boone Ying Qi Zhaoliang Li Stephen R Hann

c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF and p53. Apoptosis induced by c-Myc is a critical fail-safe mechanism for the cell to protect against unrestrained proliferation. Despite the plethora of information on c-Myc, the molecular mechanism of how c-Myc induces...

Journal: :Neuro-oncology 2023

Abstract Though long recognized as a master regulator of cell proliferation across wide range cancers, Myc has proven elusive to direct therapeutic targeting. The CDK9-containing PTEFb, complexed with either BRD4 or SEC, facilitates Myc-driven transcriptional programs and is necessary for sustaining expression itself. Advances in development clinical-grade CDK9 inhibitors creates an opportunity...

Journal: :Journal of virology 2007
Jianyong Liu Heather J Martin Gangling Liao S Diane Hayward

The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) protein is functionally pleiotropic. LANA contributes to KSHV-associated pathogenesis, in part, by increasing entry of cells into S phase through a process that is driven by LANA interaction with the serine-threonine kinase glycogen synthase kinase 3 (GSK-3) and stabilization of beta-catenin. We now sho...

Journal: :Genes & development 2014
Maralice Conacci-Sorrell Celine Ngouenet Sarah Anderson Thomas Brabletz Robert N Eisenman

Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated proteolysis of Myc. This generates Myc-nick, a cytoplasmic, transcriptionally inactive cleavage product of Myc. We found conversion of Myc into Myc-nick in cell lines and tissues derived from multiple cancers. In colon cancer, the production...

Journal: :Anticancer research 2009
Danielle Queiroz Calcagno Adriana Costa Guimarães Mariana Ferreira Leal Aline Damaceno Seabra André Salim Khayat Thais Brilhante Pontes Paulo Pimentel Assumpção Marília De Arruda Cardoso Smith Rommel Rodríguez Burbano

BACKGROUND MYC is important in gastric carcinogenesis. A few studies reported MYC translocation or insertion associated with gastric cancer. MATERIALS AND METHODS MYC copy number and its insertion, as well as the chromosomes in which MYC was inserted, were evaluated by fluorescence in situ hybridization assay in interphase and metaphase cells of 12 diffuse-type gastric cancer samples. MYC pro...

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