Triple hit lymphomas (THL) comprise a rare, heterogenous group of and like many B-cell lymphomas, chromosomal translocations are biologic diagnostic hallmarks disease. Traditionally referred to as subset double (DHL) in literature, THLs characteristically involve rearrangements c-MYC, BCL-2, BCL-6 oncogenes. Many case series high-grade lymphoma, especially MYC/BCL2 have been described the but r...

Although N-myc amplification in neuroblastomas correlates with poor prognosis, not all neuroblastomas which fail to respond to therapy have N-myc amplification. To determine whether other modes of myc gene activation underlie progression of some neuroblastomas, 45 were analyzed for amplification of N-wiyc, c-myc and L-myc and 26 were studied for transcription of these oncogenes. N-myc amplifica...

Introduction: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) are aggressive tumors poor prognosis. In virtually all HGBL-DH/TH-BCL2 tumors, is rearranged to the variable region of IGH locus, which thought occur early in differentiation during RAG-mediated VDJ recombination, leading constitutive overexpression driven by potent Eµ enhancer. We explored topolo...

The c-Myc oncoprotein is a transcription factor which is a critical regulator of cellular proliferation. Deregulated expression of c-Myc is associated with many human cancers, including Burkitt's lymphoma. The c-Myc protein is normally degraded very rapidly with a half-life of 20 to 30 min. Here we demonstrate that proteolysis of c-Myc in vivo is mediated by the ubiquitin-proteasome pathway. In...

Abstract In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify complicated crosstalk of Annexin A2 (ANXA2) with Glypican 1 (GPC1) demonstrate whether combined indexes ANXA2 GPC1 could improve prognostic evaluation patients. We found that ANXA2-induced cell proliferation c-Myc-dependent manner. increased expression via c-Myc upregulated ...

c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF and p53. Apoptosis induced by c-Myc is a critical fail-safe mechanism for the cell to protect against unrestrained proliferation. Despite the plethora of information on c-Myc, the molecular mechanism of how c-Myc induces...

Abstract Though long recognized as a master regulator of cell proliferation across wide range cancers, Myc has proven elusive to direct therapeutic targeting. The CDK9-containing PTEFb, complexed with either BRD4 or SEC, facilitates Myc-driven transcriptional programs and is necessary for sustaining expression itself. Advances in development clinical-grade CDK9 inhibitors creates an opportunity...

The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) protein is functionally pleiotropic. LANA contributes to KSHV-associated pathogenesis, in part, by increasing entry of cells into S phase through a process that is driven by LANA interaction with the serine-threonine kinase glycogen synthase kinase 3 (GSK-3) and stabilization of beta-catenin. We now sho...

Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated proteolysis of Myc. This generates Myc-nick, a cytoplasmic, transcriptionally inactive cleavage product of Myc. We found conversion of Myc into Myc-nick in cell lines and tissues derived from multiple cancers. In colon cancer, the production...

BACKGROUND MYC is important in gastric carcinogenesis. A few studies reported MYC translocation or insertion associated with gastric cancer. MATERIALS AND METHODS MYC copy number and its insertion, as well as the chromosomes in which MYC was inserted, were evaluated by fluorescence in situ hybridization assay in interphase and metaphase cells of 12 diffuse-type gastric cancer samples. MYC pro...