OBJECTIVE To compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis, posterior uveitis, or panuveitis. DESIGN Multicenter, block-randomized, observer-masked clinical trial. PARTICIPANTS Eighty patients with noninfectious intermediate, posterior, or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Mad...

chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. ...

BACKGROUND Dermatomyositis (DM) is a multisystem idiopathic inflammatory disorder that most commonly affects the muscles and skin. Systemic corticosteroids are the mainstay of therapy but are limited by their long-term adverse effects. OBSERVATIONS We sought to evaluate the effectiveness of oral mycophenolate mofetil in patients with cutaneous lesions of DM recalcitrant to other therapies thr...

The introduction of the immunosuppressive agent mycophenolate mofetil as a standard-dose drug has resulted in a reduced risk of rejection after renal transplantation and improved graft survival compared to azathioprine. The favorable balance between efficacy and safety has made mycophenolate mofetil a cornerstone immunosuppressive drug, and the vast majority of newly transplanted patients are n...

PURPOSE Between September 20, 1995 and September 20, 1996, 120 patients were entered into a prospective, randomized trial comparing tacrolimus and prednisone with (61) and without (59) 2 gm. mycophenolate mofetil daily to determine whether mycophenolate mofetil was associated with a lower incidence of rejection. MATERIALS AND METHODS Mean recipient age plus or minus standard deviation was 50....

background despite the advances in the treatment of chronic hepatitis b virus (hbv) infection, liver transplantation (lt) remains the only hope for many patients with end-stage liver diseases resulting from hbv. objectives the aim of this study was to investigate the rate of hbv recurrence in cases that had undergone lt due to the hbv related liver cirrhosis. patients and methods forty-nine pat...

Mycophenolic acid has gained widespread acceptance as the antimetabolite of choice in most of the immunosuppressive regimens, thanks to its selective action versus T and B cells. This drug is characterized by a narrow therapeutic index and a well-documented relationship between efficacy (in terms of acute rejection episodes) and exposure to mycophenolic acid (as AUC and C0). For these reasons, ...

mycophenolate mofetil (mmf) as an immunosuppressive agent is used to prevent graft rejection. one of the adverse effects of long time administration of mmf is the gastrointestinal disorder. this study aimed to investigate the gastroprotective effect of silymarin (smn) on mmf-induced gastrointestinal (gi) disorders. twenty-four adult female wistar rats were assigned into three groups including t...

ABSTRACTQUESTION One of my female patients conceived 2 years after renal transplant while using mycophenolate mofetil. She only realized she was pregnant at 14 weeks of gestation. How should I advise her?ANSWER Several recent case series show increased malformation rates with mycophenolate mofetil. Specifically, the repeated occurrence of phenotypic presentations of ear malformations, cleft lip...