Van Melle et al (2007) reported that cardiac prognosis post-myocardial infarction was not improved by antidepressant treatment (MIND–IT trial). The SADHART and ENRICHD trials reported similar findings and Carney & Freedland (2007), in their commentary in the same issue, suggest these negative findings are a result of insufficient statistical power in the trials. These results are disappointing ...

Unfortunately, depression is now a well documented independent risk factor of coronary artery disease. Post-myocardial infarction (MI) patients with a clinician-diagnosed depressive disorder or self-reported depressive symptoms carry a 2.0to 2.5-fold increased relative risk of new cardiovascular events and cardiac mortality Questions about the pathophysiologic mechanism of depression in this se...

The purpose of this study was to determine the coronary angiographic correlations (specifically disease of the left anterior descending coronary artery) of reciprocal ST segment depression appearing during inferior acute myocardial infarction. Forty six patients (41 men and five women; mean age 56 years) were allocated into two groups based on the extent of precordial ST segment depression: wid...

To determine electrocardiographic changes and whether myocardial ischemia occurs during cesarean section, electrocardiograms were recorded continuously using Holter monitoring in 25 patients undergoing elective cesarean section under either spinal or epidural anesthesia. In addition, in 13 of the patients, two-dimensional precordial echocardiography was carried out before and during cesarean se...

BACKGROUND Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis. AIMS To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study. METHOD In a multicentre randomised controlled trial, 2177 myocardial infarction ...

Background-—Depression is prevalent in coronary heart disease (CHD) patients and increases risk for acute coronary syndrome (ACS) recurrence and mortality despite optimal medical care. The pathways underlying this risk remain elusive. Psychological stress (PS) can provoke impairment in myocardial perfusion and trigger ACS. A confluence of acute PS with depression might reveal coronary vascular ...

BACKGROUND Patients with acute myocardial infarction may have worse outcomes if they also have a history of depression. The early management of acute myocardial infarction is known to influence outcomes, and patients with a coexisting history of depression may be treated differently in the emergency department than those without one. Our goal was to determine whether having a charted history of...

background: national transport commission (ntc) classifies train driving as a high-level safety critical job. objective: to assess fitness-for-work among train drivers in yazd, central iran. methods: we evaluated 152 train drivers for their fitness for duty. the results were then compared with ntc guidelines. results: 63.8% of subjects were fit for duty, 34.2% fit subject to review, and 2.0% we...

A 61-year old lady presented clinically in unstable angina with ST-segment depression typical of myocardial ischemia. However, coronary arteries were completely normal at angiography. Exercise testing reproduced symptoms and ST-segment depression. A diagnosis of Syndrome X was made, an uncommon disorder of myocardial ischemia with normal coronary anatomy and excellent prognosis.