A new method of visualizing acute myocardial infarction in humans following intravenous injection of 15 mCi-5 mg of 99mTc stannous pyrophosphate in 23 patients is reported. Fifteen patients had histories suggestive of acute myocardial infarction and subsequently developed electrocardiogram and enzyme changes that confirmed the clinical diagnosis. Eleven of the 15 patients were scanned 3-5 days ...

The objective of the study aims to evaluate the combined protective effects of coenzyme Q10 and magnesium sulphate on isoproterenol induced myocardial damage in rats. CoenzymeQ10 (50 mg/kg) and magnesium sulphate (10 mg/kg) were administered orally to wistar rats in individual or in combination for 30 days.  At the end of this period, rats were administered isoproterenol (85 mg/kg i.p.) intrape...

Background & Aims: Myocardial infarction is one of the most common life threatening diseases in worldwide. Betaine is a safe and well tolerated compound that shows beneficial antioxidant and anti-inflammatory properties. Previous studies demonstrated, betaine reduce cardiovascular diseases but molecular mechanism of action did not known completely. Cathepsin G play pivotal role in tissue injury...

A modified method for the measurement of total creatine phosphokinase release from venous blood samples taken four-hourly after myocardial infarction has been used in 43 patients admitted to a Coronary Care Unit. The fractional decay rate (KD) of enzyme activity has been measured by a standardized method in each patient, and accuracy of the calculation of total enzyme release has been improved ...

1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

BACKGROUND Danshen-Gegen decoction (DG), a Chinese herbal formula, has been demonstrated to be effective for the treatment of coronary heart disease such as myocardial infarction. In the present study, we investigated the effect of DG post-conditioning on isoproterenol (ISO)-induced myocardial injury in rats. METHODS ISO was injected intraperitoneally (200 mg/kg) to induce acute (2-6 hours) m...

Purine nucleoside phosphorylase (PNP) in mammalian tissue is an enzyme responsible for formation of purine bases in DNA. It is also believed that PNP is crucial under energy-deprived conditions for the cell to metabolise adenosine during ATP degradation. This work describes a new method for determination of PNP activity in myocardial tissue using a commercially available substrate, 2-amino-6-me...

1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

Objective: To explore the protective role of exogenous Creatine Phosphate (PCr) in the postoperative cardiac muscle recovery in children undergoing open heart surgery. Material and methods: 63 cases of congenital heart disease were randomly divided into 3 groups; A, B and C; 21 cases in each group. Myocardial perfusion fluids were made of the same amount of blood in the St, Thomas Hospital card...

Background: Coastal areas have a high bacterial diversity, which can be used as source of pharmaceutical substances, including the fibrinolytic enzyme. Fibrinolytic enzymes lyse blood clots by degrading fibrin. These are important for treating circulatory disorders, e.g., pulmonary embolism, deep vein thrombosis, and myocardial infarction. Objective: This study aimed to determine activity crude...