Background Arterial stiffness increases pressure load to the left ventricle (LV), leading to LV hypertrophy and subendocardial ischemia. Neurohormones stimulate myocardial fibrosis and LV dysfunction. We aimed to explore the associations of arterial stiffness and plasma aldosterone with multi-directional, layer-specific LV, and left atrial (LA) mechanical function in hypertensive patients. Me...

BACKGROUND Effective risk stratification is integral to management of acute coronary syndromes (ACS). The Thrombolysis in Myocardial Infarction (TIMI) risk score for ST-segment elevation myocardial infarction (STEMI) is a simple integer score based on 8 high-risk parameters that can be used at the bedside for risk stratification of patients at presentation with STEMI. OBJECTIVES To evaluate t...

Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yi...

physicochemical and mechanical properties of wheat grains can have a great impact on the quality of the final products (bread). therefore, correct selection of wheat cultivar for specific applications seems to be crucial. in this study, the differences in the physicochemical and mechanical properties (under compression and impact loadings) of ten iranian wheat cultivars (azar2, alamut, bam, bah...

The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MVO2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased MVO2 and did not i...

Abstract Background To date, there is little data regarding the clinical significance of myocardial work (MW) parameters after a stable period following acute infarction (AMI). Purpose investigate additional prognostic value MW AMI. Methods Between 2018 and 2020, 244 patients admitted in cardiac intensive care unit university hospital for AMI were included. One-month AMI, comprehensive transtho...

in the present study,cardioprotective effect of aqueous extract of garcinia indica linn. fruit rinds in isoprenaline-induced myocardial infarction in wistar albino rats was evaluated. in vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. in vivo effect of aqueous extract of g. indica was evaluated in wistar albino ...

Irreversible myocardial failure due to severe ischemia is a challenging problem in clinical practice. The present study was performed to evaluate the potential benefit of mechanical circulatory support in a bovine model with prolonged, acute myocardial ischemia. Seven calves (74+6 kg) underwent 6 hours of regional ischemia by temporary (6h) ligation of the left circumflex coronary artery. Ventr...