2 Magnetic particle imaging (MPI) is a medical imaging technology used for noninvasive diagnostics. However, the image resolution achieved with MPI is degraded due to imperfections in the MPI system and the characteristics of magnetic nanoparticles (MNPs). A reconstruction method that reduces image blurring is proposed herein to overcome this problem. Herein, we compare our image reconstruction...

Background Quantitative analysis can improve myocardial perfusion imaging (MPI) for prediction of prognosis. We have designed a novel approach, Decisions Informed by Computed Entities (DICE), to enhance the prognostic ability of MPI data to predict major adverse cardiovascular events (MACE) in women with suspected ischemic heart disease. We applied DICE to cardiovascular magnetic resonance imag...

Magnetic particle imaging (MPI) is a new tomographic imaging method potentially capable of rapid 3D dynamic imaging of magnetic tracer materials. Until now, only dynamic 2D phantom experiments with high tracer concentrations have been demonstrated. In this letter, first in vivo 3D real-time MPI scans are presented revealing details of a beating mouse heart using a clinically approved concentrat...

background: we sought to assess right ventricular (rv) systolic and diastolic functions via tissue doppler imaging (tdi) in order to discriminate right-to-left (bidirectional) from left-to-right intracardiac shunts. methods: a tissue doppler velocity study via doppler echocardiography was performed in 20 patients with left-to-right shunt (without evidence of significant pulmonary hypertension) ...

Background—Because of its brief hemodynamic effects and minor effect on determinants of myocardial oxygen demand, vasodilator stress myocardial perfusion imaging (MPI) can be applied very early after acute myocardial infarction (AMI) for risk stratification, allowing management decisions to be made earlier and thus potentially shortening hospitalization stays, reducing costs, and preventing ear...

BACKGROUND Fractional flow reserve (FFR) measured on catheterization is now widely used for the diagnosis of functional myocardial ischemia in patients with coronary artery disease (CAD). FFR, however, is invasive and carries potential procedural complications. Therefore, the aim of this study was to compare the diagnostic capability in functionally significant stenosis identified on FFR, betwe...

Objective(s): Inhaled aerocontaminants are removed from the lungs by pulmonary mucociliary transport (MCT) as an important defense mechanism. This study was undertaken to investigate the influence of the surface potential of magnetic nanoparticles (MNPs) on the MCT in murine lungs by use of magnetic particle imaging (MPI).Materials and Methods: Three kinds of MNPs (carboxymethyl dextran m...

Objective(s): To appropriately use one-day myocardial perfusion imaging (MPI) with 99mTc radiopharmaceuticals (i.e. to avoid shine-through artifacts), injection doses need to be optimized and dose ratios between the 1st and 2nd scans should be maintained at ≥ 3. However, the current state of practice in Japan is unclear. Thus, the aim of this study was to clarify the details of MPI protocols us...

OBJECTIVES Our purpose was to describe a novel, rapid stress thallium-201 (Tl-201)/rest technetium-99m (Tc-99m) agent myocardial perfusion imaging (MPI) protocol (Tl/Tc) with a high-speed MPI scanner and to compare this protocol with a standard rest/stress Tc-99m agent protocol (Tc/Tc) with respect to image quality and radiation dosimetry. BACKGROUND Recent advances in gamma camera technology...

stress-only MPI SPECT (≈3 mSv), rest-stress MPI PET Rubidium-82 (≈3 mSv), and rest-stress MPI PET 13N (≈2 mSv) are represented in the recent consensus document (3). In addition, as defined by the authors, novel SPECT camera technology may allow us to reduce radiation doses with SPECT imaging (5). Stress-only MPI use may be encouraged whenever possible to reduce radiation exposure. Finally, in f...