7-con-O-Methylnogarol (7-OMEN), a new analog of the an thracycline antibiotic, nogalamycin, has chemotherapeutic ac tivity in several experimental mouse tumor systems. As part of the preclinical development of 7-OMEN, the cardiotoxic poten tial was evaluated in chronically dosed rabbits. Groups of 4 rabbits were dosed twice weekly i.v. with 11 or 33 mg/sq m/ week for 12 weeks, 110 sq m/mg/week ...

BACKGROUND Enteroviruses have been considered as the most common etiologic agents in clinical myocarditis and dilated cardiomyopathy; however, their pathogenetic role remains unknown. Hence, the relation of viral replication and development of cardiomyopathy has been determined in a murine model of myocarditis by evaluating the persistence of viral genome during acute and chronic stages of myoc...

BACKGROUND The causal role of asymptomatic critical coronary artery obstruction in patients presenting with severe global biventricular dysfunction but no evidence of myocardial infarction is uncertain. METHODS AND RESULTS Among 291 patients aged >40 years undergoing a noninvasive (2-dimensional echocardiography) and invasive (catheterization, coronary angiography, and biventricular endomyoca...

Objective(s): Carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. These new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. Up to now, all aspects of carbon nanotubes toxicity are not com...

Objective(s): Due to wide range of medical applications as bactericidal agents, nanosilver particles (NSPs) are manufactured worldwide in large quantities. However, potential toxicity impacts of NSPs in humans and animals still remain poorly understood. The objective of this study was to investigate clinical observations, mortality and pathological changes in rats follow...

Background Patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM) often develop a rapidly progressive interstitial lung disease (RP-ILD) associated high mortality [1] . Objectives to evaluate clinical features and prognosis of patients anti-MDA5+ DM who developed RP-ILD. Methods Anti-MDA5+ were selected from single center cohort 198 idi...

Background Background: Anti-Melanoma Differentiation-Associated gene 5 (MDA-5) Dermatomyositis (MDA5, DM) is a rare systemic autoimmune disease, characteristically associated with Rapidly Progressive Interstitial Lung Disease (RP-ILD) and cutaneous manifestations. Anti-MDA5 dermatomyositis may develop in genetically predisposed subjects after environmental exposure such as vaccines, infections ...

700 the echocardiography performed during and after treatment, LVEF was still normal, but longitudinal function of both ventricles was increased: LV-GLS was –17.4% and RV-FWS was –24.3%. The biopsies performed weekly during the first month after heart transplantation revealed no additional signs of significant rejection (1a, 2, 1a ISHLT grade). Echocardiography performed in the 2nd month after ...