Objective(s): Staphylococcus epidermidis is a common cause of medical device-associated infections due to biofilm formation, and its elimination is extremely challenging. Although rifampin efficacy against S. epidermidis biofilms has been confirmed, its use as a single agent may lead to resistance. As such, it is assumed that the combination of rifampin and N-acetylcysteine (NAC) could exert ad...

Background: Acetaminophen is a popular antipyretic and analgesic medication worldwide; however, its therapeutic window narrow, which may lead to overdose or toxicity. This study was conducted assess the correlation between serum acetaminophen levels before 4 hours after acute toxicity with this drug. The objective of test validity level arrive at clinical decision on acetaminophen. Methods: cro...

Background: This study takes a microscopic overview of main semen parameters such as sperm motility, morphology, fertility rate, concentration, and DNA damage their relationship with antioxidants. Aim: To explain the role antioxidant minerals including Vitamin E C, N-Acetyl cysteine, Selenium, Carnitine, CoQ10, Zinc in improving quality across parameters. Methods: The design is an in-depth revi...

Novel SF5-bearing maleimide and acrylamide derivatives were synthesised as potential [18F]radio-prosthetic groups for radiolabelling peptides proteins. The efficacy of selected prosthetic was first assessed through bioconjugation with protected model amino acid derivatives. These reactions investigated on an analytical scale via LC-MS across a pH range to quantitatively evaluate this group’s re...

Background Poly cystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. The role of insulin-resistance (IR) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. N acetyl cysteine (NAC) i...

This study was designed to evaluate the protective effect of N-acetyl cysteine in reducing methylmercury (MeHg)-induced oxidative stress, lipid peroxidation, DNA damage in liver, kidney, and brain, and their ability to restore altered hepatic, renal, and other biochemical variables. Male Sprague-Dawley rats (150±10 g) were randomly divided into three groups. Group 1 served as the control. Group...

In this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. AD fibroblasts showed the highest levels of oxidative stress, and the antioxidants, l...