Antibiotic resistance of pathogenic strains microorganisms is one the most difficultproblems modern medicine. An effective way to solve it synthesis new classesof antibacterial and antifungal drugs with a wide spectrum antiseptic action.Purpose research – types glycolic acid acylhydrazones(quinolin-8-yl)and investigation their antimicrobe activity.Material methods. The analysis activity wascarr...

Bis-acylhydrazones of 2,6-pyridinedicarbaldehyde are introduced as planar pentadentate ligands for the coordination of lanthanide(III) ions. With large cations (e.g. lanthanum(III)) 1 : 1 as well as 2 : 1 ligand-to-metal complexes are formed depending on the stoichiometry of the reaction. The different complexes are distinguished by NMR spectroscopy and ESI MS in solution and they can be charac...

Fragment-based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported. Dynamic combinatorial chemistry (DCC) has become a powerful hit-identification strategy for biological targets. We report the synergistic combination of fragment linking and DCC to identify inhibi...

Sexually transmitted Chlamydia trachomatis is an extremely common infection and often leads to serious complications including infertility and pelvic inflammatory syndrome. Several broad-spectrum antibiotics are currently used to treat C. trachomatis. Although effective, they also kill beneficial vaginal lactobacilli. Two N-acylhydrazones, CF0001 and CF0002, have been shown previously to inhibi...