The synthesis of S-glycosyl sulfonamides wherein the primary sulfonamide functional group (-SO(2)NH(2)) is directly attached to the anomeric position of a carbohydrate moiety is reported. Our general approach consists of first introducing a thioacetate group at the anomeric center of a per-O-acetylated sugar derivative. From this follows formation of a glycosyl sulfenamide (sugar-SNR(2)), oxida...

Epoxide hydrolase (EH) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. These enzymes present different enantio- and regioselectivity depending upon either the substrate structure or the substitution pattern of the epoxide ring. In this study, we computationally investigate the Bacillus megaterium epoxide hydrolase (BmEH)-mediated hydrolysis of race...

Objectives: The objective of this endeavour is to prepare βcyclodextrin (β-CD) inclusion complex with sulfonamide (SAP) using the co-evaporation technique and screened its effect on in-vitro antimicrobial property against some Gram-positive and Gramnegative bacteria. Methods: A new sulfonamide SAP (4-amino-N-(1, 5-dimethyl-3oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) benzene sulfonamide) 4 has b...

Styrene-specific N-7- and O6-guanine DNA adducts and N-terminal valine adducts were determined in mice tissues after the intraperitoneal administration of styrene. Blood, liver, lungs and spleen were collected 3 h after administration of various doses (from 0 to 4.35 mmol/kg b.w.) of styrene. DNA adducts were analysed by the modified 32P-postlabelling assay and N-terminal valine adducts were de...

Research findings concerning benzene, toluene, ethylobenzene, meta-, para- and ortho-xylene as well as styrene (BTEXS) emission at public cemeteries during All Saints' Day are presented here. Tests were carried out at town-located cemeteries in Opole and Grodków (southern Poland) and, as a benchmark, at the centres of those same towns. The purpose of the study was to estimate BTEXS emissions ca...

There are two mol-ecules in the asymmetric unit of the title compound, C(11)H(10)N(3)O(4)S(+)·NO(3) (-). All bond distances have normal values. The C-N bond distances in the sulfonamide group [1.389 (3) and 1.382 (3) Å] may indicate slight conjugation of the sulfonamide N-atom π-electrons with those of the pyridinium ring. The crystal structure is stabilized by N-H⋯O hydrogen bonds.

Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding to an extracellular site located at the interface of two adjacent subunits. In contrast, recent studies have provided evidence that positive allosteric modulators (PAMs) such as TQS (4-(naphthalen-2-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) and allosteric agonists such as 4BP-TQS (4-(4-bromophe...

OBJECTIVE To determine whether hepatic biochemical changes, as measured by routinely available tests indicative of hepatocellular necrosis, cholestasis, or altered hepatic clearance of bilirubin, occur in association with low to moderate exposure to styrene commonly experienced in industrial production. METHODS Two independent cross sectional studies were performed comparing serum hepatic tra...

Visualizing proton-transfer processes at the nanoscale is essential for understanding the reactivity of zeolite-based catalyst materials. In this work, the Brønsted-acid-catalyzed oligomerization of styrene derivatives was used for the first time as a single molecule probe reaction to study the reactivity of individual zeolite H-ZSM-5 crystals in different zeolite framework, reactant and solven...