The fibrous tissues prevalent throughout the body possess an ordered structure that underlies their refined and robust mechanical properties. Engineered replacements will require recapitulation of this exquisite architecture in three dimensions. Aligned nanofibrous scaffolds can dictate cell and matrix organization; however, their widespread application has been hindered by poor cell infiltrati...

Nanofibrous structures developed by electrospinning technology provide attractive extracellular matrix conditions for the anchorage, migration, and differentiation of tissue cells, including those responsible for the regeneration of hard tissues. Together with the ease of set up and cost-effectiveness, the possibility to produce nanofibers with a wide range of compositions and morphologies is t...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

Poly(lactide-co-glycolide) (PLGA) nanofibrous composite scaffolds having nano-hydroxyapatite particles (HAp) in the fibers were prepared by electrospinning of PLGA and HAp with an average diameter of 266.6 ± 7.3 nm. Microscopy and spectroscopy characterizations confirmed integration of the crystalline HAp in the scaffolds. Agglomerates gradually appeared and increased on the fiber surface along...

Hierarchical, titania-coated, nanofibrous, carbon hybrid materials were fabricated by employing natural cellulosic substances (commercial filter paper) as a scaffold and carbon precursor. Ultrathin titania films were firstly deposited by means of a surface sol-gel process to coat each nanofiber in the filter paper, and successive calcination treatment under nitrogen atmosphere yielded the titan...

Humidity indicators based on composite polyamide 66/cobalt chloride (PA66/CoCl2) nanofibrous membranes (NFMs) were successfully fabricated by electrospinning. A series of NFMs with various weight percentage of CoCl2 to PA66 were prepared, and their humidity sensitivity based on color changing and quartz crystal microbalance (QCM) were studied. Due to the color change property of cobalt chloride...

Dear Friends, Nanofibrous scaffolds have been a major revolution in the field of tissue engineering which may improve the health and quality of life by enhancing tissue function. These are the artificial extracellular matrices which offer natural surroundings for tissue formation. Owing to their high surface to volume ratio, nanofibrous scaffolds increase cell adhesion, proliferation, and diffe...

Aligned nanofibrous scaffolds hold tremendous potential for the engineering of dense connective tissues. These biomimetic micropatterns direct organized cell-mediated matrix deposition and can be tuned to possess nonlinear and anisotropic mechanical properties. For these scaffolds to function in vivo, however, they must either recapitulate the full dynamic mechanical range of the native tissue ...

The structural features of tissue engineering scaffolds affect cell response and must be engineered to support cell adhesion, proliferation and differentiation. The scaffold acts as an interim synthetic extracellular matrix (ECM) that cells interact with prior to forming a new tissue. In this review, bone tissue engineering is used as the primary example for the sake of brevity. We focus on nan...