Nanotechnology is an emerging technology seeking to exploit distinct technological advances of controlling the structure of materials at a reduced dimensional scale approaching individual molecules and their organised aggregates or supramolecular structures. These technological innovations, referred to as nanomedicines by the National Institutes of Health (Bethesda, MD, USA), have the potential...

Nanomedicines that preferentially deploy cytotoxic agents to tumors andmolecular targeted therapeutics that inhibit specific aberrant oncogenic drivers are emerging as the new paradigm for the management of cancer. While combination therapies are a mainstay of cancer chemotherapy, few studies have addressed the combination of nanomedicines and molecular targeted therapeutics. Furthermore, limit...

Silk has a robust clinical track record and is emerging as a promising biopolymer for drug delivery, including its use as nanomedicine. However, silk-based nanomedicines still require further refinements for full exploitation of their potential; the application of "stealth" design principals is especially necessary to support their evolution. The aim of this study was to develop and examine the...

The leading cause of death in the world, cardiovascular disease (CVD), remains a formidable condition for researchers, clinicians and patients alike. CVD comprises broad collection diseases spanning heart, vasculature blood that runs through interconnects them. Limitations therapeutic diagnostic landscapes have generated excitement advances nanomedicine, field focused on improving patient outco...

The treatment of cancer using nanomedicines is limited by the poor penetration of these potentially powerful agents into and throughout solid tumors. Externally controlled mechanical stimuli, such as the generation of cavitation-induced microstreaming using ultrasound (US), can provide a means of improving nanomedicine delivery. Notably, it has been demonstrated that by focusing, monitoring and...