Background: Apremilast (APR) is an orally administered selective phosphodiesterase 4 inhibitor approved to treat plaque psoriasis and psoriatic arthritis available as oral tablet formulation. However, its systemic side effects limit application. The low solubility permeability of apremilast make it difficult administer through the skin. Hence attempt made incorporate into a suitable nanocarrier...

The aim of this review is to discuss the development nanostructured lipid carrier (NLC) by application quality design (QbD). QbD started with evolution concept and slow adaptation guidelines, which has now become a regulatory requirement. In review, brief history elements including risk assessment (RA) have been discussed followed experiments (DoEs) that acts as tool analyze input whose variati...

Objective: The aim of present study was to prepare triamcinolone acetonide (TA) loaded NLCs hydrogel for antipsoriatic activity. Methods: A Nanostructured lipid carrier (NLCs) prepared by using solvent diffusion and high pressure homogenization methods. dispersion characterized particle size, zeta potential, scanning electron microscopy (SEM), differential calorimetry, an in vitro release study...

Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as biocompatible, non-toxic, safe nano-drug compared to polymeric or metallic nanoparticles. Due its safety, stability, high loading capacity other lipid-based nanocarriers, NLC gained ...